{"id":"W1528478735","doi":"10.1139/jpn.0312","title":"Interactions between the cytochrome P450 system and the second-generation antipsychotics","year":2003,"lang":"en","type":"article","venue":"Journal of Psychiatry and Neuroscience","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Hospital Edmonton; University of Alberta","funders":"","keywords":"Olanzapine; Quetiapine; Ziprasidone; CYP1A2; CYP2D6; Pharmacology; Risperidone; Cytochrome P450; CYP3A4; Clozapine; Sertindole; CYP2C19; Atypical antipsychotic; Medicine; Drug; Antipsychotic; Metabolism; Psychiatry; Internal medicine; Schizophrenia (object-oriented programming)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002155996,0.0001195155,0.0001890723,0.00006771292,0.0006989366,0.00008298889,0.0002351021,0.00005551123,0.00003864918],"category_scores_gemma":[0.00008472655,0.00006488112,0.0000719849,0.000203894,0.0004691799,0.0001615375,0.00002926698,0.0006615196,0.000002030387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000736404,"about_ca_system_score_gemma":0.00008334576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.62248e-7,"about_ca_topic_score_gemma":0.000004314575,"domain_scores_codex":[0.998247,0.000869436,0.0003956476,0.0001494735,0.0001558996,0.0001825746],"domain_scores_gemma":[0.9989958,0.0003276943,0.0003408594,0.000115752,0.00007186221,0.00014797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007635586,0.0004086657,0.04661972,0.0001726259,0.000215993,0.00003107856,0.001860069,0.0007821592,0.7933203,0.1358888,0.01205308,0.007883903],"study_design_scores_gemma":[0.009059115,0.0004247584,0.1601309,0.00006435462,0.001020916,0.004852009,0.0009914043,0.009251933,0.03417916,0.005369253,0.7741509,0.0005052878],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838212,0.003200766,0.0008349106,0.004431866,0.006312646,0.0001766553,0.00001584268,0.000006904423,0.001199195],"genre_scores_gemma":[0.9951965,0.0009596198,0.0001650283,0.002748648,0.0007359862,0.00000292214,1.783134e-7,0.000006713313,0.0001843846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7620978,"threshold_uncertainty_score":0.5375726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09750897274758721,"score_gpt":0.4072555498554237,"score_spread":0.3097465771078365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}