{"id":"W1528578169","doi":"10.1177/135965350701200810","title":"Amphipathic DNA Polymers are Candidate Vaginal Microbicides and Block Herpes Simplex Virus Binding, Entry and Viral Gene Expression","year":2007,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources; National Institute of Allergy and Infectious Diseases","keywords":"Herpes simplex virus; Biology; Virology; Microbicides for sexually transmitted diseases; HeLa; Viral entry; Virus; Viral shedding; DNA; Avidity; Molecular biology; Viral replication; Immunology; Cell; Biochemistry; Antibody; Medicine; Population","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002030445,0.0002694877,0.0003216853,0.0001816928,0.0002790689,0.00005197587,0.00004480995,0.000143586,0.00006740265],"category_scores_gemma":[0.000007759382,0.0002080175,0.00006875122,0.000145349,0.0001753551,0.0001452671,0.0000354999,0.0001528393,0.00001661663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004048127,"about_ca_system_score_gemma":0.00003109596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004989587,"about_ca_topic_score_gemma":0.00009642677,"domain_scores_codex":[0.9987826,0.00005305255,0.0002361446,0.0003684813,0.0001505838,0.0004091828],"domain_scores_gemma":[0.99946,0.00004643601,0.0001115879,0.0002004068,0.00002986478,0.0001517026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005453409,0.0003017888,0.1459273,0.00001871912,0.000159203,0.0001985105,0.0003573642,7.900407e-8,0.6237861,0.00001332437,0.0001461363,0.2285462],"study_design_scores_gemma":[0.00363507,0.0003956631,0.1196587,0.0001318869,0.00005571534,0.0001387384,0.0001402151,0.000004497173,0.841781,0.00004224844,0.03377276,0.0002434333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960431,0.002784408,0.00004702515,0.0001324382,0.000121451,0.0002922,0.00003890496,0.00007480131,0.000465702],"genre_scores_gemma":[0.9952762,0.003247028,0.000284768,0.0004423807,0.0001555994,0.000008032137,0.0000254841,0.00003641679,0.0005240763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2283028,"threshold_uncertainty_score":0.8482707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01530328335931878,"score_gpt":0.2860751315980268,"score_spread":0.270771848238708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}