{"id":"W1528825864","doi":"10.1002/9780470015902.a0024873","title":"Mitochondrial <scp>DNA</scp> Copy Number Alterations in Human Cancers","year":2012,"lang":"en","type":"other","venue":"Encyclopedia of Life Sciences","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Tianjin Science and Technology Committee; Beijing Municipal Science and Technology Commission","keywords":"Mitochondrial DNA; Biology; Mitochondrion; Cancer; Oxidative phosphorylation; Cancer cell; Carcinogenesis; Cancer research; Genetics; Somatic cell; Mitochondrial disease; Cell biology; Molecular biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000197228,0.000238781,0.0003190839,0.0001783936,0.00009277665,0.00001516333,0.0003832114,0.0004100845,0.001603737],"category_scores_gemma":[0.0003092366,0.0002201843,0.0001016323,0.0002486004,0.0004432404,0.000007576926,0.00008556218,0.0001476947,0.00009854383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001631036,"about_ca_system_score_gemma":0.0004522929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006138091,"about_ca_topic_score_gemma":0.002101964,"domain_scores_codex":[0.9983904,0.0001382151,0.0003618027,0.0004966292,0.0002467,0.0003662827],"domain_scores_gemma":[0.9991921,0.00003963833,0.000285722,0.0003023311,0.00003354437,0.0001467216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007055713,0.00005330389,0.01460178,0.00002555405,0.00002319398,0.000001352484,0.0001658277,0.00002142181,0.01932016,0.0004911607,0.9651867,0.0001024657],"study_design_scores_gemma":[0.0003895424,0.0001286063,0.0002288543,0.00003709211,0.00001562899,0.000003734496,0.0001193854,0.000001263129,0.00265487,0.00004890589,0.9962504,0.0001217439],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.01683235,0.001376415,0.000205445,0.00004252418,0.005184148,0.0003322646,0.00008755185,0.00002238741,0.9759169],"genre_scores_gemma":[0.007938956,0.002506957,0.004535558,0.0004592274,0.008894121,0.0001165231,0.0003129015,0.0001623587,0.9750734],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.03106365,"threshold_uncertainty_score":0.9993089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01487679253608946,"score_gpt":0.2832630838432098,"score_spread":0.2683862913071203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}