{"id":"W1529045195","doi":"10.12973/ejac/78054","title":"Impurity profile: Significance in Active Pharmaceutical Ingredient","year":2007,"lang":"en","type":"article","venue":"Eurasian Journal of Analytical Chemistry","topic":"Analytical Chemistry and Chromatography","field":"Chemistry","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Active ingredient; Ingredient; Impurity; Chemistry; Process engineering; Chromatography; Business; Biochemical engineering; Computer science; Pharmacology; Medicine; Food science; Engineering; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000789488,0.0003700259,0.0006453954,0.0001007072,0.00006959501,0.00004767872,0.0006161267,0.0003465626,0.003036088],"category_scores_gemma":[0.0005654517,0.0003385229,0.0004851694,0.0006568733,0.0004668218,0.0001921732,0.00008679547,0.001769603,0.00001487779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002904295,"about_ca_system_score_gemma":0.0002024236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002609232,"about_ca_topic_score_gemma":0.000001077298,"domain_scores_codex":[0.9966733,0.00002192241,0.001312587,0.0004136567,0.0007814867,0.0007970707],"domain_scores_gemma":[0.9977697,0.0003233705,0.0004526704,0.000324105,0.0002675483,0.0008626389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002916521,0.002530728,0.06626797,0.001657644,0.0007533025,0.007018056,0.0005258895,0.00004500393,0.9051359,0.0004630651,0.00257225,0.01011369],"study_design_scores_gemma":[0.001693277,0.00004673588,0.002559792,0.0003003544,0.0001527854,0.0006198001,0.001421177,0.0007534809,0.9871452,0.0004420295,0.00438712,0.0004782253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8590708,0.0002183634,0.0004865371,0.0003780617,0.00005885863,0.00003978522,0.00001786554,0.00003311688,0.1396966],"genre_scores_gemma":[0.9980929,0.00003313793,0.0003462481,0.00007198269,0.0006998469,0.000001617657,0.000009057538,0.00003033557,0.0007148522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1390221,"threshold_uncertainty_score":0.9999067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486813078055053,"score_gpt":0.2966111302825596,"score_spread":0.281742999502009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}