{"id":"W1529045195","doi":"10.12973/ejac/78054","title":"Impurity profile: Significance in Active Pharmaceutical Ingredient","year":2007,"lang":"en","type":"article","venue":"Eurasian Journal of Analytical Chemistry","topic":"Analytical Chemistry and Chromatography","field":"Chemistry","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Active ingredient; Ingredient; Impurity; Chemistry; Process engineering; Chromatography; Business; Biochemical engineering; Computer science; Pharmacology; Medicine; Food science; Engineering; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002196979,0.0007476435,0.001003997,0.004090631,0.0006715971,0.003400783,0.0009909543,0.001292016,0.005369657],"category_scores_gemma":[0.004533424,0.0002433405,0.0006995851,0.005108914,0.001048401,0.002106093,0.001222278,0.001564133,0.002640163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001202377,"about_ca_system_score_gemma":0.001126854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001542499,"about_ca_topic_score_gemma":0.001118917,"domain_scores_codex":[0.9958794,0.0004445986,0.0003443481,0.0006111243,0.002508623,0.0002118109],"domain_scores_gemma":[0.9950476,0.001196891,0.001356314,0.0002981812,0.001923443,0.0001777477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001279595,0.0005233106,0.05059635,0.007162217,0.0003718185,0.003602603,0.0005734882,0.003234844,0.1332058,0.02664403,0.02831941,0.7444866],"study_design_scores_gemma":[0.00006620649,0.001932487,0.07416082,0.002437575,0.0008549351,0.01614448,0.001423977,0.01220679,0.2468446,0.02613775,0.6174681,0.0003223775],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.258927,0.4313307,0.1050186,0.01202653,0.0034226,0.0008371583,0.01195628,0.00203518,0.174446],"genre_scores_gemma":[0.8051322,0.1008316,0.04874436,0.003869935,0.001928397,0.0002365728,0.005920575,0.0004058754,0.03293047],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005369657,"threshold_uncertainty_score":0.01796329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486813078055053,"score_gpt":0.2966111302825596,"score_spread":0.281742999502009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}