{"id":"W1529895897","doi":"10.4049/jimmunol.165.2.997","title":"Skin-Specific Caspase-1-Transgenic Mice Show Cutaneous Apoptosis and Pre-Endotoxin Shock Condition with a High Serum Level of IL-18","year":2000,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research & Development Corporation","funders":"Howard Hughes Medical Institute","keywords":"Proinflammatory cytokine; Apoptosis; In vivo; Genetically modified mouse; Transgene; Molecular biology; DNA fragmentation; Keratinocyte; Caspase 1; Caspase; Biology; Chemistry; Immunology; Programmed cell death; In vitro; Inflammation; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001828749,0.0001678972,0.0002699042,0.00006582928,0.00009495328,0.00001041736,0.0002710452,0.0001485168,0.000298132],"category_scores_gemma":[0.00000928405,0.0001159951,0.00008993509,0.00008262935,0.0003144111,0.0000117724,0.00002975227,0.0002247391,0.000004626383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001293994,"about_ca_system_score_gemma":0.00006706836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004388584,"about_ca_topic_score_gemma":0.0000303229,"domain_scores_codex":[0.9989814,0.0001658983,0.0003814371,0.0001271323,0.0001108988,0.0002333014],"domain_scores_gemma":[0.999277,0.00003672553,0.0002569823,0.0002589121,0.000141963,0.00002844938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002701059,0.00007537037,0.00008403986,0.00001297336,0.0005220274,0.000005135762,0.0004230001,0.0001587932,0.9892863,0.0000202022,0.0004840981,0.006226968],"study_design_scores_gemma":[0.001877229,0.002528381,0.004495711,0.00003884541,0.0001256437,0.002120617,0.000625588,0.000003244696,0.9800991,0.00008837913,0.007823917,0.0001732774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948816,0.004120096,0.0002140553,0.0002650622,0.0001029488,0.0001410922,0.00005137311,0.000002902333,0.0002208417],"genre_scores_gemma":[0.9915363,0.00758205,0.0001566615,0.00009317049,0.00007219989,0.000003003712,0.00002053589,0.00002073146,0.0005153831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009187168,"threshold_uncertainty_score":0.4730144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127047312311812,"score_gpt":0.2198315952924251,"score_spread":0.2085611221693069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}