{"id":"W1529953445","doi":"10.1161/01.cir.0000074251.89176.6d","title":"Regional Pathologies and Globalization of Clinical Trials: Has the Time for Regional Trials Arrived?","year":2003,"lang":"en","type":"letter","venue":"Circulation","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"","keywords":"Medicine; Clinical trial; Population; Heart failure; Spironolactone; Internal medicine; Gerontology; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.1391085,0.0008637523,0.00498907,0.001370584,0.00363278,0.01592069,0.003406068,0.05030847,0.00893619],"category_scores_gemma":[0.3337949,0.001212893,0.001982171,0.002787933,0.0243159,0.01883932,0.004725713,0.07721774,0.003427647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01072198,"about_ca_system_score_gemma":0.01815195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005588769,"about_ca_topic_score_gemma":0.008543426,"domain_scores_codex":[0.9091645,0.07244898,0.004795105,0.004359577,0.007152561,0.002079213],"domain_scores_gemma":[0.4104784,0.5178098,0.02272988,0.01317214,0.01914073,0.016669],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000769346,0.00009257176,0.002339716,0.0007948244,0.000244474,0.0007610786,0.0009678437,0.000645451,0.0001991939,0.1937475,0.7421545,0.05728339],"study_design_scores_gemma":[0.001493873,0.000274989,0.002979289,0.002337284,0.0002078787,0.001249342,0.001483455,0.002628811,0.0003126417,0.4120095,0.5747487,0.000274254],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.000121127,0.003553901,0.000845862,0.9919512,0.002889647,0.000005256065,0.00001313106,0.000009668416,0.0006101799],"genre_scores_gemma":[0.009204923,0.005342646,0.003227543,0.9140701,0.06680117,0.0001251545,0.00001904441,0.00007188561,0.001137459],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.8608915,"threshold_uncertainty_score":0.7356846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.888804080787102,"score_gpt":0.6312691889108916,"score_spread":0.2575348918762105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}