{"id":"W1530222901","doi":"10.3390/antibiotics1010001","title":"Classification Framework and Chemical Biology of Tetracycline-Structure-Based Drugs","year":2012,"lang":"en","type":"review","venue":"Antibiotics","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Antifungal; Interchangeability; Computational biology; Schematic; Tetracycline; Lipophilicity; Computer science; Chemistry; Biology; Antibiotics; Stereochemistry; Biochemistry; Microbiology; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008039157,0.0003287452,0.0008856712,0.00003890086,0.00004813561,0.00001497724,0.0003112607,0.00122019,0.0002720231],"category_scores_gemma":[0.0001682684,0.0002905634,0.0002107884,0.0001850497,0.000290534,0.00001929834,0.00007121221,0.0006371359,0.00001524523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003598775,"about_ca_system_score_gemma":0.00009658499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002351408,"about_ca_topic_score_gemma":1.485928e-7,"domain_scores_codex":[0.998623,0.00001596983,0.0006144844,0.0003814893,0.0001210136,0.0002440878],"domain_scores_gemma":[0.9980218,0.0005754708,0.0005445936,0.0006758819,0.00007197505,0.000110249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000004063657,0.0002101228,0.000291936,0.02966368,0.000130042,4.444066e-7,0.00003414189,1.012108e-7,0.03342641,0.004767663,0.0001217882,0.9313496],"study_design_scores_gemma":[0.00009246796,0.000003159739,0.000002812081,0.002454541,0.0007797934,0.000009746686,0.00001361099,0.00001813904,0.08703685,0.0005013088,0.9087589,0.0003286541],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002547041,0.9945062,0.0001709356,0.00006323976,0.0000671063,0.0001241015,0.000722919,0.00004836266,0.001750068],"genre_scores_gemma":[0.121347,0.8735759,0.002733446,0.00001778667,0.0004854816,0.000001692815,0.00165601,0.00004801225,0.0001347738],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.931021,"threshold_uncertainty_score":0.9999546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05200553254785666,"score_gpt":0.3531061897989149,"score_spread":0.3011006572510582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}