{"id":"W1530470155","doi":"10.1080/23723556.2015.1006077","title":"(-)-Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization","year":2015,"lang":"en","type":"article","venue":"Molecular & Cellular Oncology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; University of Victoria","keywords":"Programmed cell death; Cancer cell; Apoptosis; Cell biology; Acid sphingomyelinase; Lysosome; Cell; Biology; Cell culture; Cell membrane; Cell growth; Cancer; Chemistry; Biochemistry; Ceramide; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002178858,0.0002506956,0.0004471057,0.00009215999,0.00007856164,0.0000161048,0.000102199,0.0002905725,0.0002196405],"category_scores_gemma":[0.00003620844,0.0002327485,0.00009563547,0.000182223,0.0001317963,0.00009257154,0.00005442828,0.0002107844,0.00002343524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000309769,"about_ca_system_score_gemma":0.0007162801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000355776,"about_ca_topic_score_gemma":0.00003941359,"domain_scores_codex":[0.9983808,0.0002268146,0.0002647425,0.0004627899,0.000295979,0.0003688912],"domain_scores_gemma":[0.99898,0.00003327648,0.0001200505,0.0002533409,0.0002156327,0.0003977097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004359981,0.0004630814,0.003519119,0.0000607563,0.0001562071,0.0007948556,0.0007888473,0.00005982876,0.9881721,0.0002161926,0.000091013,0.005242054],"study_design_scores_gemma":[0.00425464,0.001406176,0.003450436,0.00002319022,0.0003584739,0.0001491152,0.0002472275,0.001404315,0.9831841,0.0004449561,0.004802304,0.0002750727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795713,0.009931218,0.003544089,0.0004470395,0.0002243351,0.0004966388,0.000006202393,0.00007871244,0.005700493],"genre_scores_gemma":[0.9968063,0.0003305096,0.0007629505,0.001430375,0.0001844997,0.00007629463,0.00006004652,0.00005170012,0.0002973187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01723503,"threshold_uncertainty_score":0.9491209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02358104509196364,"score_gpt":0.3002333550707575,"score_spread":0.2766523099787939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}