{"id":"W1530470155","doi":"10.1080/23723556.2015.1006077","title":"(-)-Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization","year":2015,"lang":"en","type":"article","venue":"Molecular & Cellular Oncology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; University of Victoria","keywords":"Programmed cell death; Cancer cell; Apoptosis; Cell biology; Acid sphingomyelinase; Lysosome; Cell; Biology; Cell culture; Cell membrane; Cell growth; Cancer; Chemistry; Biochemistry; Ceramide; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006295677,0.0002144307,0.0001649803,0.0001595322,0.00008849073,0.0001550459,0.00008620247,0.0001464087,0.0007079897],"category_scores_gemma":[0.00007849446,0.00006179787,0.0001798346,0.000126571,0.0001277998,0.0001263792,0.0001557995,0.0002282783,0.0001343576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001905917,"about_ca_system_score_gemma":0.0001788261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005579043,"about_ca_topic_score_gemma":0.001059885,"domain_scores_codex":[0.9999362,0.000009916072,0.00000484611,0.000008196632,0.00001375246,0.00002707339],"domain_scores_gemma":[0.9999554,0.00001228387,0.00001172126,0.000006689744,0.000005258146,0.000008639974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002881653,0.00003558182,0.0001791145,0.00003396219,0.000006520323,0.00006950714,0.00001338391,0.00007259784,0.997915,0.00006880258,0.0000440444,0.001273427],"study_design_scores_gemma":[0.000008258476,0.0003356214,0.001151774,0.000002396567,0.00000630641,0.0001149226,0.00001006729,0.0001700017,0.9973683,0.00001708641,0.000813973,0.000001262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996627,0.001185135,0.0008825255,0.00003768448,0.00001496396,0.00001749327,0.0001868144,0.00003468818,0.001013665],"genre_scores_gemma":[0.997118,0.0007904225,0.0006037444,0.00003204406,0.000007068988,0.00001984325,0.0002970775,0.000007604051,0.001124399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007079897,"threshold_uncertainty_score":0.00236845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02358104509196364,"score_gpt":0.3002333550707575,"score_spread":0.2766523099787939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}