{"id":"W1530976754","doi":"10.1158/1538-7445.am2014-2905","title":"Abstract 2905: The activity of a new class of biologics: trastuzumab conjugates designed to treat brain metastases of HER2+ breast cancers","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"","keywords":"Trastuzumab; SKBR3; Antibody-dependent cell-mediated cytotoxicity; Monoclonal antibody; Cytotoxicity; Medicine; Breast cancer; Conjugate; Cancer research; In vivo; Antibody; Cancer; Pharmacology; In vitro; Immunology; Chemistry; Internal medicine; Biology; Biochemistry; Human breast","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001114633,0.0003912926,0.0002133486,0.0001879796,0.00009402648,0.0002175735,0.0001606601,0.0002067199,0.001185589],"category_scores_gemma":[0.00008184178,0.00006546433,0.0001536025,0.0001719868,0.00009030864,0.0001106537,0.000136242,0.0002402941,0.0003861591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002217204,"about_ca_system_score_gemma":0.0001404265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004371239,"about_ca_topic_score_gemma":0.0003469831,"domain_scores_codex":[0.9999367,0.000012319,0.00000499094,0.00001192301,0.00002183153,0.00001228252],"domain_scores_gemma":[0.9999686,0.000003288631,0.000007194206,0.000002102008,0.000005915005,0.0000127915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001539953,0.00006083179,0.0002855427,0.0000390674,0.000009240869,0.00004286583,0.000007682086,0.0001651778,0.9935631,0.00007334085,0.0001340973,0.005465151],"study_design_scores_gemma":[0.00008541448,0.001329843,0.00550183,0.000008883932,0.0000341733,0.0005584893,0.000008073876,0.001288631,0.9829292,0.00003388293,0.008215551,0.000005907808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885938,0.003960647,0.003678075,0.00007948824,0.00004345361,0.00007593811,0.0003110302,0.0000652731,0.003192256],"genre_scores_gemma":[0.9912834,0.001300437,0.003043291,0.00007752562,0.00002342202,0.00002891834,0.0009023356,0.00001767459,0.003323079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001185589,"threshold_uncertainty_score":0.003966212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1024113189590185,"score_gpt":0.4239348184027095,"score_spread":0.321523499443691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}