{"id":"W1532042963","doi":"10.18632/oncotarget.2699","title":"RNA interference screening identifies a novel role for PCTK1/CDK16 in medulloblastoma with c-Myc amplification","year":2014,"lang":"en","type":"article","venue":"Oncotarget","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hospital for Sick Children; European Commission; University of Bern","keywords":"Kinome; RNA interference; Cancer research; Medulloblastoma; Biology; PI3K/AKT/mTOR pathway; Kinase; Cell growth; Gene knockdown; Molecular biology; Signal transduction; Cell culture; Cell biology; Gene; RNA; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001888528,0.0001399118,0.0001417663,0.00005344912,0.00005394621,0.00003750863,0.000196199,0.0001067532,0.000006772129],"category_scores_gemma":[0.00006695232,0.000127197,0.00005045792,0.00007048473,0.00004537949,0.000007951932,0.00005853428,0.00007085394,0.000005629858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001440947,"about_ca_system_score_gemma":0.00003596615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005649578,"about_ca_topic_score_gemma":0.0008170022,"domain_scores_codex":[0.9991466,0.00002196526,0.0001874375,0.0003406762,0.00007425122,0.0002290681],"domain_scores_gemma":[0.9994799,0.00001826408,0.00009008712,0.000279538,0.00008153627,0.00005066534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001756981,0.00007042295,0.006375267,0.00002154944,0.00002309711,1.849713e-7,0.000092088,0.0001622915,0.9903123,0.0003879266,0.0005081382,0.001870989],"study_design_scores_gemma":[0.003033068,0.001129959,0.02233293,0.0001980203,0.00004438045,0.0000205415,0.0004941727,0.01052572,0.8568619,0.0004740858,0.1041668,0.0007184925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6874214,0.00009257156,0.3115918,0.00009713671,0.00005612169,0.000189874,0.00002193227,0.00001044914,0.0005187514],"genre_scores_gemma":[0.9854898,0.00002527132,0.01317152,0.0002027592,0.0001348666,0.00008943041,0.0002394854,0.00002488867,0.0006220089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2984203,"threshold_uncertainty_score":0.5186942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009195516007473257,"score_gpt":0.238206942606239,"score_spread":0.2290114265987658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}