{"id":"W1532670577","doi":"10.1038/75452","title":"Universal DNA array detection of small insertions and deletions in BRCA1 and BRCA2","year":2000,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":207,"is_retracted":false,"has_abstract":false,"ca_institutions":"Coalition for Research in Women's Health; University of Toronto","funders":"National Cancer Institute","keywords":"Frameshift mutation; Amplicon; Biology; Oligonucleotide; Genetics; Multiplex; Polymerase chain reaction; Multiplex polymerase chain reaction; Molecular biology; Context (archaeology); Population; DNA sequencing; Multiplex ligation-dependent probe amplification; Mutation; DNA; Gene; Exon","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006557842,0.0005552542,0.0006588381,0.0006535526,0.0003573142,0.0004998613,0.0006575186,0.0008677618,0.002360772],"category_scores_gemma":[0.001006565,0.0005116769,0.0003777241,0.0003819469,0.000478825,0.00053367,0.0007869262,0.001098089,0.0009079657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000665091,"about_ca_system_score_gemma":0.000426165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005366014,"about_ca_topic_score_gemma":0.002308181,"domain_scores_codex":[0.9991486,0.0001106684,0.00003975786,0.0003450256,0.000196087,0.0001599045],"domain_scores_gemma":[0.9993569,0.0002511501,0.0001098729,0.0000899454,0.00006974712,0.0001223964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005532554,0.00001450338,0.0001651232,0.00002581863,0.00000453215,0.00001924505,0.00001281629,0.00007131873,0.9967302,0.0002163941,0.0001533132,0.002531352],"study_design_scores_gemma":[0.000008710749,0.00006528938,0.00114548,0.000004145688,0.000009667646,0.0001229127,0.00001154652,0.0009485943,0.9963337,0.0001137109,0.001229771,0.000006434085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.775215,0.00284594,0.208613,0.0006692193,0.0002871283,0.0001715911,0.002531539,0.00279426,0.006872311],"genre_scores_gemma":[0.8405805,0.001063631,0.1411902,0.0006332569,0.00004235403,0.0003384232,0.003657234,0.0003248945,0.01216941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002360772,"threshold_uncertainty_score":0.007897556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002464149416619745,"score_gpt":0.2231205657012266,"score_spread":0.2206564162846069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}