{"id":"W1532938669","doi":"10.4049/jimmunol.1201941","title":"IL-21 Enhances Phagocytosis in Mononuclear Phagocyte Cells: Identification of Spleen Tyrosine Kinase as a Novel Molecular Target of IL-21","year":2013,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research","keywords":"Syk; Phagocytosis; Mononuclear phagocyte system; Biology; Cell biology; Macrophage; Monocyte; Flow cytometry; Endocytosis; Tyrosine kinase; Phagocyte; Downregulation and upregulation; Cell; Molecular biology; Signal transduction; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001108083,0.0003219985,0.000335506,0.0001554893,0.0001485823,0.0002739922,0.0001221288,0.0002867734,0.0008886319],"category_scores_gemma":[0.00009520316,0.00007582099,0.0003244813,0.0001058984,0.000193493,0.0001683839,0.0002156065,0.0003998751,0.000270464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002438349,"about_ca_system_score_gemma":0.0001820577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001339378,"about_ca_topic_score_gemma":0.0001843413,"domain_scores_codex":[0.9998903,0.00002302809,0.000008572825,0.00001675171,0.00002872886,0.00003253274],"domain_scores_gemma":[0.9999413,0.00001157377,0.00001613415,0.000006297195,0.000009185961,0.00001552525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00011599,0.0000116677,0.0001100895,0.00004155947,0.000002885484,0.00006833283,0.00000673632,0.00002665682,0.9990129,0.00004993356,0.00000907161,0.0005441498],"study_design_scores_gemma":[0.00001930309,0.0002889504,0.006285887,0.000005523776,0.00001426154,0.0004857826,0.00001486872,0.0008106906,0.9910286,0.00006208858,0.0009807791,0.000003281136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923368,0.003604368,0.00266681,0.0001379648,0.00003152495,0.00002817042,0.0001250622,0.00002906176,0.001040277],"genre_scores_gemma":[0.9962423,0.001094949,0.001516704,0.00005315095,0.00001751449,0.00002287634,0.0001510004,0.000005845609,0.0008958264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008886319,"threshold_uncertainty_score":0.002972841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008324510784692539,"score_gpt":0.2284156260922822,"score_spread":0.2200911153075897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}