{"id":"W1533379125","doi":"10.1038/35087061","title":"Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1","year":2001,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":241,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Permissiveness; Biology; Protein kinase R; Herpes simplex virus; 3T3 cells; Oncolytic virus; Virology; Kinase; Virus; Cancer cell; Cell biology; Protein kinase A; Cell culture; Transfection; Viral replication; Cancer; Genetics; Mitogen-activated protein kinase kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004311719,0.0003457016,0.0003391315,0.0002031569,0.0001076889,0.00002573821,0.0005992656,0.0009522788,0.0001667247],"category_scores_gemma":[0.00007691756,0.0003140758,0.0001386549,0.000372194,0.0001068742,0.000004552988,0.000216498,0.0004639175,0.00008447257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005140068,"about_ca_system_score_gemma":0.0002290639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006975624,"about_ca_topic_score_gemma":0.001214386,"domain_scores_codex":[0.9975567,0.0003512838,0.0003252371,0.0008294055,0.0001573271,0.0007799901],"domain_scores_gemma":[0.9989755,0.00007076713,0.00008974498,0.0004783025,0.0001538542,0.0002318613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001979918,0.0001888791,0.001243315,0.00001948671,0.00002376178,0.00006435297,0.0000724274,0.0003582289,0.9734154,0.000006058059,0.0002715899,0.02235663],"study_design_scores_gemma":[0.00087987,0.001400797,0.0001962692,0.00000839004,0.000004835506,0.00000599673,0.00004893393,0.00003277892,0.7611996,0.00004671334,0.2358732,0.000302607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880592,0.008897751,0.0001738406,0.0003265259,0.0002267075,0.0004382065,0.00006851098,0.00002585093,0.001783455],"genre_scores_gemma":[0.9943775,0.001740677,0.0001888238,0.001776819,0.0004103657,0.00006522521,0.0002705218,0.00005990452,0.00111016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2356016,"threshold_uncertainty_score":0.9999312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01337418354891114,"score_gpt":0.3022595400613269,"score_spread":0.2888853565124158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}