{"id":"W1534029327","doi":"10.1161/circ.124.suppl_21.a506","title":"Abstract 14193: Dynamin-Related Protein 1 (DRP1)-Mediated Mitochondrial Fission Promotes Smooth Muscle Cell Hyperproliferation in Human and Experimental Pulmonary Hypertension Which Can be Therapeutically Targeted by the Fission Inhibitor MDIVI-1","year":2011,"lang":"en","type":"article","venue":"Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Mitochondrial fission; Medicine; DNM1L; Fission; Cell biology; Pharmacology; Mitochondrion; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003455166,0.0004565121,0.0003846976,0.000275144,0.0004934262,0.0005597395,0.0003469391,0.0006329824,0.007361922],"category_scores_gemma":[0.0002476575,0.0002880838,0.0002677873,0.0001297418,0.0004432144,0.0003254848,0.0002738007,0.002055646,0.001345699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007631261,"about_ca_system_score_gemma":0.0005049384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009501952,"about_ca_topic_score_gemma":0.001543949,"domain_scores_codex":[0.9998798,0.0000206527,0.000009303239,0.00002363891,0.00003268621,0.00003387719],"domain_scores_gemma":[0.9999148,0.00001859153,0.00001730699,0.00000786193,0.00001115207,0.0000302289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006506572,0.0003737548,0.0003519283,0.0002519091,0.00005048893,0.0009402067,0.00006894309,0.0003946905,0.9416884,0.004001316,0.01868348,0.02668824],"study_design_scores_gemma":[0.001659347,0.002677476,0.01496865,0.0001135996,0.0001279599,0.00265822,0.0001633918,0.002584791,0.9006016,0.002338324,0.07206566,0.00004091923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.862699,0.05502854,0.009031811,0.03138632,0.007003151,0.0002527417,0.002975843,0.0008541904,0.03076837],"genre_scores_gemma":[0.9338127,0.01306025,0.003090216,0.001328904,0.00111423,0.0001416907,0.002487177,0.0001286514,0.04483616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007361922,"threshold_uncertainty_score":0.02462804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02764777147541463,"score_gpt":0.2573917887740792,"score_spread":0.2297440172986646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}