{"id":"W1534586188","doi":"10.1111/j.1471-4159.2010.06887.x","title":"ABCG2 reduces ROS‐mediated toxicity and inflammation: a potential role in Alzheimer’s disease","year":2010,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Institute for Biological Sciences","funders":"Canadian Institutes of Health Research","keywords":"Oxidative stress; Reactive oxygen species; Inflammation; Cell biology; NF-κB; Signal transduction; Chemistry; Heme; Proinflammatory cytokine; Pharmacology; Biology; Cancer research; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001276506,0.0001048328,0.0002078785,0.00006150352,0.00003015991,0.00001821209,0.00008263429,0.00008225584,0.00005678021],"category_scores_gemma":[0.00009433368,0.00008563929,0.00007918194,0.00008734697,0.00005634786,0.0000953845,0.00001171907,0.0004886126,0.00000125419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007646039,"about_ca_system_score_gemma":0.0001474059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.61052e-7,"about_ca_topic_score_gemma":0.00000251363,"domain_scores_codex":[0.9991243,0.000008812824,0.0003515143,0.0001172728,0.0002650361,0.0001330866],"domain_scores_gemma":[0.9993018,0.00001758902,0.0001822767,0.0001084341,0.0001014165,0.0002884811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004288987,0.0001142805,0.002974868,0.00004064883,0.00002170013,0.0009075545,0.0000631367,0.000004296005,0.9944727,0.000003972877,0.00004725672,0.0009206309],"study_design_scores_gemma":[0.003086866,0.0001080915,0.2973729,0.0002034854,0.000291913,0.0008090974,0.0001837529,0.0002327406,0.6959481,0.0003481123,0.001234206,0.0001807533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973149,0.0005125427,0.00001140291,0.001589241,0.0002120468,0.00006284558,0.000004510608,0.0000101558,0.0002822991],"genre_scores_gemma":[0.9989707,0.0001180229,0.0002422328,0.00008412195,0.0004919546,0.000001408711,0.000006960831,0.00001122965,0.00007338067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2985247,"threshold_uncertainty_score":0.3492269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006212123126943051,"score_gpt":0.232525641826309,"score_spread":0.2263135186993659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}