{"id":"W1534658079","doi":"10.4049/jimmunol.173.2.932","title":"Adenosine Acts through A2 Receptors to Inhibit IL-2-Induced Tyrosine Phosphorylation of STAT5 in T Lymphocytes: Role of Cyclic Adenosine 3′,5′-Monophosphate and Phosphatases","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; China Scholarship Council; Faculty of Medicine, Dalhousie University; Dalhousie University; Nova Scotia Health Research Foundation","keywords":"Protein tyrosine phosphatase; Adenosine; Phosphorylation; Tyrosine phosphorylation; Forskolin; Adenosine A2B receptor; Adenylyl cyclase; Biology; Receptor tyrosine kinase; Tyrosine kinase; Chemistry; Cell biology; Adenosine receptor; Signal transduction; Molecular biology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152996,0.000356319,0.0002020786,0.0001312789,0.0001677709,0.0002435141,0.0001261145,0.0002577861,0.001450609],"category_scores_gemma":[0.00005061893,0.00009587257,0.000273533,0.000106966,0.0001418507,0.0001839322,0.0001003486,0.000480797,0.000293534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001931178,"about_ca_system_score_gemma":0.0001971273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005151235,"about_ca_topic_score_gemma":0.001114757,"domain_scores_codex":[0.9998995,0.00002256519,0.00001044477,0.00001575223,0.00001639022,0.00003524043],"domain_scores_gemma":[0.9999733,0.000004307848,0.000007295541,0.000002755908,0.000002783237,0.000009576648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000271738,0.00006190759,0.0001240557,0.00008498174,0.00000835751,0.00007559311,0.00001013975,0.00006196264,0.9974126,0.0001153069,0.00008549369,0.001687854],"study_design_scores_gemma":[0.0001712624,0.002022417,0.01252174,0.00001939032,0.00006546355,0.000603447,0.00004396956,0.001698863,0.9760342,0.0001143326,0.006692417,0.0000123905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766104,0.01505062,0.002910815,0.0003611023,0.0001740065,0.00008007615,0.0004822224,0.00006802192,0.004262685],"genre_scores_gemma":[0.9921256,0.003747656,0.001462157,0.0001333611,0.00006799213,0.00006761496,0.0003786233,0.000006562838,0.00201047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001450609,"threshold_uncertainty_score":0.004852712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009563038552825507,"score_gpt":0.24127022297217,"score_spread":0.2317071844193445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}