{"id":"W1534852475","doi":"10.1016/j.cell.2015.06.003","title":"Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice","year":2015,"lang":"en","type":"article","venue":"Cell","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":279,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"International AIDS Vaccine Initiative; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Center for Advancing Translational Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; European Research Council; National Institutes of Health; Vetenskapsrådet; Aids Fonds; Howard Hughes Medical Institute; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Biology; Germline; Immunization; Antibody; Virology; Immune system; Vaccination; Immunology; HIV vaccine; Glycoprotein; Neutralizing antibody; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008762543,0.001808613,0.001036015,0.001771718,0.0007760194,0.001111338,0.001182271,0.002259474,0.005116389],"category_scores_gemma":[0.0002693268,0.0008147563,0.001092101,0.0004669687,0.0009768347,0.0008424505,0.0004721327,0.007027397,0.001448919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007598226,"about_ca_system_score_gemma":0.0005254759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001189339,"about_ca_topic_score_gemma":0.001192713,"domain_scores_codex":[0.9989976,0.0001142818,0.00009439214,0.0003003457,0.0001473119,0.0003460488],"domain_scores_gemma":[0.9995269,0.00009483222,0.0001171492,0.00009389307,0.00004289287,0.0001243937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009651291,0.0009738416,0.0002252845,0.00007581987,0.00005415673,0.000143942,0.00008296523,0.0002098679,0.9937313,0.0006229708,0.0006954468,0.00221927],"study_design_scores_gemma":[0.0005773606,0.002661045,0.001680743,0.00003730696,0.0001743961,0.0006193638,0.00009025739,0.001547206,0.9838529,0.0003353661,0.008400925,0.00002312045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9666201,0.002286977,0.01161594,0.001593744,0.001041684,0.001061321,0.005546133,0.001996316,0.008237775],"genre_scores_gemma":[0.9656295,0.002094903,0.00886107,0.001397562,0.0002863844,0.001058247,0.003784356,0.0004126957,0.01647528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005116389,"threshold_uncertainty_score":0.01711607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0362787923901878,"score_gpt":0.2997479034136025,"score_spread":0.2634691110234146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}