{"id":"W1534852475","doi":"10.1016/j.cell.2015.06.003","title":"Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice","year":2015,"lang":"en","type":"article","venue":"Cell","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":279,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"International AIDS Vaccine Initiative; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Center for Advancing Translational Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; European Research Council; National Institutes of Health; Vetenskapsrådet; Aids Fonds; Howard Hughes Medical Institute; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Biology; Germline; Immunization; Antibody; Virology; Immune system; Vaccination; Immunology; HIV vaccine; Glycoprotein; Neutralizing antibody; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001416681,0.00008353982,0.0001235119,0.00008505669,0.00009559642,0.0000122661,0.0001078876,0.00008818619,0.00005639041],"category_scores_gemma":[0.00002447873,0.00007497107,0.00003305369,0.00006993813,0.00005649691,0.00005633036,0.00003870059,0.00009595756,0.0007115328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004893085,"about_ca_system_score_gemma":0.00004145267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002236868,"about_ca_topic_score_gemma":0.00009186742,"domain_scores_codex":[0.9993567,0.00008425296,0.0001287019,0.0001441484,0.00001654824,0.0002695846],"domain_scores_gemma":[0.9997148,0.00004757444,0.00003202113,0.0001296675,0.00005377256,0.00002215451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001557007,0.0004125313,0.03097252,0.00005247498,0.0000544034,0.00001174138,0.002071632,0.00004554636,0.9314232,0.0004612263,0.03312436,0.001214654],"study_design_scores_gemma":[0.00736899,0.0004727037,0.0162188,0.00004047616,0.00002516877,0.00001068974,0.001039735,0.00001349664,0.8069645,0.0004105777,0.1671979,0.0002369349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882428,0.003509524,0.0001711759,0.0001790608,0.000149304,0.0003321874,0.00005154773,0.00003423872,0.007330182],"genre_scores_gemma":[0.9903963,0.00004526128,0.0001461575,0.00002626086,0.00001606699,0.00002980912,0.0008733047,0.00001055647,0.008456336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1340735,"threshold_uncertainty_score":0.9145553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0362787923901878,"score_gpt":0.2997479034136025,"score_spread":0.2634691110234146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}