{"id":"W1535004310","doi":"10.1002/cncr.28414","title":"Molecular determinants of outcome with mammalian target of rapamycin inhibition in endometrial cancer","year":2013,"lang":"en","type":"article","venue":"Cancer","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Princess Margaret Cancer Centre","funders":"Princess Margaret Cancer Foundation; Kreftforeningen","keywords":"PTEN; Medicine; KRAS; Endometrial cancer; PI3K/AKT/mTOR pathway; Tensin; Temsirolimus; Cancer research; Oncology; Biomarker; Internal medicine; Cancer; Stathmin; Sirolimus; Biology; Gene; Discovery and development of mTOR inhibitors; Colorectal cancer; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000127943,0.0001646034,0.0003182001,0.0001201447,0.00001344893,0.00000668604,0.0001043249,0.0001423987,0.0003102513],"category_scores_gemma":[0.00005179958,0.0001439065,0.00007882616,0.0002568644,0.0001226356,0.000009123295,0.00004880756,0.00008546944,0.000001819978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006100747,"about_ca_system_score_gemma":0.0001602309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001258192,"about_ca_topic_score_gemma":0.0004705751,"domain_scores_codex":[0.9988098,0.00004949951,0.0004032187,0.0002963255,0.0001928338,0.0002483797],"domain_scores_gemma":[0.9992269,0.00001243279,0.0002530848,0.0002762507,0.0001709467,0.00006036972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001842365,0.00003643337,0.2473715,0.00008448395,0.00003294589,0.000007135523,0.00003755909,0.0009505007,0.7493429,0.000004626723,0.0001987626,0.001748919],"study_design_scores_gemma":[0.001801001,0.0002567826,0.02276303,0.0001200436,0.00002074175,0.000003143923,0.00002133382,0.00005958301,0.9740619,0.00003088218,0.0006797702,0.000181799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966716,0.002196074,0.0002500347,0.00005382571,0.0002311292,0.0003482287,0.00008695783,0.000004493395,0.0001576269],"genre_scores_gemma":[0.9986657,0.0001271884,0.0005023554,0.0001342281,0.00013796,0.0002634899,0.00001691315,0.00003069496,0.0001215019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.224719,"threshold_uncertainty_score":0.5868335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01543744321826466,"score_gpt":0.2904594221699635,"score_spread":0.2750219789516988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}