{"id":"W1535251520","doi":"10.1111/cbdd.12042","title":"Peptide Scanning for Studying Structure‐Activity Relationships in Drug Discovery","year":2012,"lang":"en","type":"review","venue":"Chemical Biology & Drug Design","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Peptidomimetic; Drug discovery; Peptide; Chemical space; Computational biology; Drug development; Combinatorial chemistry; Amino acid; Chemistry; Biological activity; Cyclic peptide; Drug; Biochemistry; Biology; In vitro; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001844012,0.001622274,0.001932199,0.003776197,0.0004252207,0.001303753,0.001775718,0.002155395,0.003613855],"category_scores_gemma":[0.001438922,0.0006221994,0.0007214514,0.003844358,0.001709226,0.002599159,0.001290412,0.004048345,0.00517125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001478959,"about_ca_system_score_gemma":0.0009814191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001040846,"about_ca_topic_score_gemma":0.00162056,"domain_scores_codex":[0.9991178,0.0002209763,0.00006703883,0.0001202342,0.0004281821,0.00004579042],"domain_scores_gemma":[0.9992573,0.0004374372,0.0000706466,0.00003757498,0.0001573592,0.00003965176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007184434,0.0001188651,0.0001269762,0.01464715,0.0001346697,0.0003282809,0.0001035107,0.000759628,0.007065695,0.02715817,0.0570987,0.8923865],"study_design_scores_gemma":[0.00001821001,0.00006892601,0.0002631024,0.001668395,0.00004981475,0.00103467,0.00003501598,0.0001571939,0.001479128,0.004431442,0.9907643,0.00002992321],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000743155,0.9964337,0.0009092306,0.0003348583,0.0005216268,0.00001078553,0.00001634015,0.00001761665,0.001681546],"genre_scores_gemma":[0.0007675904,0.9959877,0.001144298,0.0003843118,0.00041663,0.00002087616,0.00002320056,0.000005257039,0.001250078],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003776197,"threshold_uncertainty_score":0.01208955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07778219482896641,"score_gpt":0.3191574504627959,"score_spread":0.2413752556338294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}