{"id":"W1535548086","doi":"10.18433/j3pg68","title":"Optimisation and Validation of a High Throughput Screening Compatible Assay to Identify Inhibitors of the Plasma Membrane Calcium ATPase Pump - a Novel Therapeutic Target for Contraception and Malaria","year":2013,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Malaria Research and Control","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Manchester Biomedical Research Centre; British Heart Foundation; Medical Research Council; National Institute for Health and Care Research","keywords":"High-throughput screening; Malaria; ATPase; Throughput; Calcium; Pharmacology; Chromatography; Chemistry; Computational biology; Virology; Medicine; Biology; Computer science; Biochemistry; Internal medicine; Enzyme; Immunology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002219333,0.0001246328,0.0003455513,0.000172542,0.0001540834,0.00008284269,0.0001713042,0.00003907052,0.0002009107],"category_scores_gemma":[0.000397401,0.00007680102,0.0001035884,0.0003480755,0.0003606449,0.0005322489,0.0000618205,0.0002333249,7.219193e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003035691,"about_ca_system_score_gemma":0.0001508266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000152369,"about_ca_topic_score_gemma":0.000001812775,"domain_scores_codex":[0.9980219,0.000174474,0.0005914695,0.0001775574,0.0007693017,0.0002652764],"domain_scores_gemma":[0.9982763,0.0004889222,0.0003732242,0.00007350786,0.0004979628,0.0002900778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009688734,0.0001925463,0.008865125,0.000147607,0.0001099526,9.907279e-7,0.0002345711,0.0006129986,0.9675626,0.0007154095,0.00008066254,0.02050866],"study_design_scores_gemma":[0.00870166,0.0006804279,0.03664781,0.0001751906,0.0003198988,0.00007424239,0.0002609946,0.1273258,0.8243289,0.0003010555,0.001076591,0.000107424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9550986,0.0003050114,0.0235213,0.01972144,0.0001800813,0.001117279,0.00001575103,0.000004926766,0.0000356189],"genre_scores_gemma":[0.9927248,0.00007742043,0.006630552,0.0003583123,0.0001587882,0.00002062509,0.000001522748,0.000007523021,0.00002045015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1432337,"threshold_uncertainty_score":0.3131855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09920975754504209,"score_gpt":0.413945570497989,"score_spread":0.3147358129529469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}