{"id":"W1535702312","doi":"10.1038/sj.bjp.0707181","title":"Endothelial dysfunction and compromised eNOS/Akt signaling in the thoracic aorta during the progression of Marfan syndrome","year":2007,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Child and Family Research Institute; University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Michael Smith Health Research BC; Child and Family Research Institute; AstraZeneca Canada; AstraZeneca; Heart and Stroke Foundation of Canada; National Marfan Foundation","keywords":"Enos; Marfan syndrome; Internal medicine; Medicine; Phenylephrine; Endocrinology; Thoracic aorta; Aorta; Sodium nitroprusside; Endothelial dysfunction; Cardiology; Nitric oxide; Nitric oxide synthase; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002883705,0.0003710604,0.0003492651,0.0003951711,0.0001902794,0.0002332795,0.0002183386,0.0006604071,0.000602485],"category_scores_gemma":[0.0003169641,0.0002129032,0.0002289555,0.0001844401,0.0002989062,0.0002219636,0.0001904268,0.0006813301,0.000134959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001954146,"about_ca_system_score_gemma":0.0001506013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004613122,"about_ca_topic_score_gemma":0.0005555958,"domain_scores_codex":[0.9998844,0.00002499646,0.00001040929,0.0000241162,0.00003513889,0.00002094756],"domain_scores_gemma":[0.9997703,0.00001866186,0.000109443,0.00001227123,0.00001613629,0.00007317286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005045827,0.0003541573,0.07202875,0.0001002337,0.00005522302,0.006372814,0.0002967695,0.0001898414,0.9085145,0.0001284628,0.0001369723,0.006776302],"study_design_scores_gemma":[0.00009981513,0.002275822,0.9271501,0.00002808405,0.0001149041,0.01481372,0.000263096,0.001026878,0.05356462,0.0001264417,0.0005220004,0.00001456459],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993368,0.0004029876,0.0001238593,0.00001619087,0.000003185777,0.000003305829,0.00002458122,0.000005266583,0.00008369837],"genre_scores_gemma":[0.9992869,0.0002784052,0.000196282,0.00001635272,0.000007479342,0.000007254275,0.00005849492,0.000001383064,0.0001473461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006604071,"threshold_uncertainty_score":0.002015531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182170724116277,"score_gpt":0.3379661226677809,"score_spread":0.3261444154266181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}