{"id":"W1535915839","doi":"10.1083/jcb.201410001","title":"Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes","year":2015,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Wellcome Trust","keywords":"PLK1; Cell biology; Mitosis; Spindle checkpoint; Cytokinesis; Biology; Multipolar spindles; Centrosome; Aurora B kinase; Polo-like kinase; Spindle apparatus; Aurora inhibitor; Mitotic exit; Aurora A kinase; PI3K/AKT/mTOR pathway; Aurora kinase; Chromosome segregation; Spindle pole body; Cell cycle; Cell division; Signal transduction; Cell; Genetics; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000624534,0.0003322139,0.0003123388,0.0003271624,0.000241323,0.0003964108,0.0002533445,0.0002387761,0.00109151],"category_scores_gemma":[0.00008596294,0.0001923817,0.0001761299,0.0001479836,0.0002516072,0.0002581875,0.0003311877,0.0004576572,0.000266987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003088783,"about_ca_system_score_gemma":0.0002043321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005318824,"about_ca_topic_score_gemma":0.0009066482,"domain_scores_codex":[0.9998932,0.000007669674,0.00001281167,0.00003232411,0.00002419607,0.00002982783],"domain_scores_gemma":[0.9998938,0.00001004379,0.00003822305,0.000009629698,0.000009793815,0.00003854922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009931863,0.00000965825,0.0002763393,0.00002043281,0.000003841977,0.0000558147,0.000008573522,0.00001692523,0.9988573,0.00009813374,0.000025028,0.0005287331],"study_design_scores_gemma":[0.000009791999,0.00006587068,0.01230938,0.000003230685,0.00001277325,0.0001752287,0.00002541875,0.0005034779,0.9845812,0.0000637399,0.002245869,0.000004094389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945254,0.001519101,0.001910813,0.000101864,0.00003192279,0.00001844085,0.0004332741,0.0000755295,0.001383646],"genre_scores_gemma":[0.9966329,0.000547188,0.0006656455,0.00003878225,0.000008449809,0.00002528548,0.0003979242,0.00001722522,0.00166663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00109151,"threshold_uncertainty_score":0.00365144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0114854728588909,"score_gpt":0.2351328895655165,"score_spread":0.2236474167066256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}