{"id":"W1536836107","doi":"10.1523/jneurosci.23-10-04034.2003","title":"Exploitation of Astrocytes by Glioma Cells to Facilitate Invasiveness: A Mechanism Involving Matrix Metalloproteinase-2 and the Urokinase-Type Plasminogen Activator–Plasmin Cascade","year":2003,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":196,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital; University of Calgary","funders":"Fondation pour la Recherche Médicale","keywords":"Plasmin; Urokinase receptor; Glioma; Astrocyte; Plasminogen activator; Matrix metalloproteinase; Urokinase; Biology; Cell culture; Extracellular matrix; Cancer research; Tissue plasminogen activator; Cell biology; Chemistry; Enzyme; Biochemistry; Neuroscience; Endocrinology; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001617542,0.0005654985,0.000280485,0.0002328626,0.0001965198,0.0004567913,0.0001400263,0.0003579922,0.0005002319],"category_scores_gemma":[0.00009208403,0.0001756201,0.0003590868,0.0001616161,0.0002005076,0.0004034113,0.000310041,0.0005740378,0.0002474968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001340389,"about_ca_system_score_gemma":0.0002308789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008490348,"about_ca_topic_score_gemma":0.001827214,"domain_scores_codex":[0.9998548,0.00002925349,0.000009653763,0.00001645909,0.00003812752,0.00005169281],"domain_scores_gemma":[0.9999281,0.00001017584,0.00001602166,0.00001110765,0.00001188933,0.00002271434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009316036,0.00003668433,0.000566355,0.00009523927,0.00000937412,0.0003446258,0.00005670852,0.00002828251,0.9958334,0.0001571797,0.00003627967,0.002742717],"study_design_scores_gemma":[0.00003307288,0.0005822462,0.01290376,0.00001271428,0.00003924047,0.001274891,0.00013762,0.0009101664,0.9811545,0.000167814,0.002774422,0.000009514421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843994,0.005857903,0.006924938,0.0002877134,0.00005658549,0.0000790123,0.0001212919,0.00008636556,0.002186807],"genre_scores_gemma":[0.9912078,0.002229658,0.004573061,0.00008920873,0.00002175846,0.00005073923,0.0001414849,0.000007510835,0.001678746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008490348,"threshold_uncertainty_score":0.001688123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02324044127890555,"score_gpt":0.2418448581296517,"score_spread":0.2186044168507462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}