{"id":"W1536836107","doi":"10.1523/jneurosci.23-10-04034.2003","title":"Exploitation of Astrocytes by Glioma Cells to Facilitate Invasiveness: A Mechanism Involving Matrix Metalloproteinase-2 and the Urokinase-Type Plasminogen Activator–Plasmin Cascade","year":2003,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":196,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital; University of Calgary","funders":"Fondation pour la Recherche Médicale","keywords":"Plasmin; Urokinase receptor; Glioma; Astrocyte; Plasminogen activator; Matrix metalloproteinase; Urokinase; Biology; Cell culture; Extracellular matrix; Cancer research; Tissue plasminogen activator; Cell biology; Chemistry; Enzyme; Biochemistry; Neuroscience; Endocrinology; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006812532,0.0001447819,0.0002110206,0.00009209284,0.0001119831,0.00004234413,0.0002708694,0.00006153379,0.000002813506],"category_scores_gemma":[0.0008131395,0.0001035442,0.00008336638,0.0002354896,0.0001246177,0.00004031699,0.00008356265,0.0001134883,9.255355e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000131575,"about_ca_system_score_gemma":0.0001235952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009412891,"about_ca_topic_score_gemma":0.000001721048,"domain_scores_codex":[0.9986758,0.0002201788,0.0003461239,0.0002348448,0.0003231424,0.0001999451],"domain_scores_gemma":[0.9991297,0.00005309889,0.0003409929,0.0001746743,0.0001702743,0.0001312374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002475109,0.00003383926,0.00000742068,0.00001602333,0.000008860558,0.00001314245,0.0001517126,0.00005128572,0.9988623,0.0003982912,0.0001626723,0.00004689485],"study_design_scores_gemma":[0.0007206595,0.001089919,0.00001416019,0.00003010055,0.00002097336,0.0001649507,0.0002907791,0.00004000193,0.9957232,0.0004014752,0.001400908,0.0001028153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944928,0.0006754851,0.00419672,0.00007615601,0.0002676787,0.0002604973,0.00001338493,0.000002443808,0.0000147784],"genre_scores_gemma":[0.9979447,0.0001800315,0.001515606,0.0002009031,0.00002810421,0.000009077139,6.509682e-7,0.0000113965,0.0001095609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003451814,"threshold_uncertainty_score":0.4222409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02324044127890555,"score_gpt":0.2418448581296517,"score_spread":0.2186044168507462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}