{"id":"W1536896113","doi":"10.1111/j.1471-4159.2012.07652.x","title":"An astrocyte‐specific enhancer of the aquaporin‐4 gene functions through a consensus sequence of POU transcription factors in concert with multiple upstream elements","year":2012,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Japan Society for the Promotion of Science","keywords":"Enhancer; POU domain; Astrocyte; Promoter; Biology; Gene isoform; Exon; Enhancer RNAs; Transcription (linguistics); Transcription factor; Molecular biology; Gene; Ccaat-enhancer-binding proteins; Regulatory sequence; Aquaporin 4; Cell biology; Gene expression; Genetics; DNA-binding protein; Biochemistry; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001559483,0.0005023925,0.0002848993,0.0003210834,0.0002152014,0.0001923599,0.0002831854,0.0002139944,0.001445244],"category_scores_gemma":[0.0001842021,0.0003154077,0.0002198112,0.0001397764,0.0003870569,0.0001769431,0.0003766285,0.0003899578,0.0006570353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003148024,"about_ca_system_score_gemma":0.0003806518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005006336,"about_ca_topic_score_gemma":0.0009548823,"domain_scores_codex":[0.9998038,0.00003088563,0.000008150464,0.00007505914,0.00004571414,0.00003634181],"domain_scores_gemma":[0.9998814,0.00003124715,0.00002913058,0.00001098305,0.00001248696,0.00003473444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008172427,0.00001983852,0.0002333576,0.00003044862,0.000002252966,0.00008836703,0.00001743212,0.00005930752,0.9969182,0.0003547047,0.00003748374,0.002156784],"study_design_scores_gemma":[0.00004132332,0.0001964583,0.009979201,0.00001749486,0.0000128059,0.0006055231,0.00003538835,0.002262879,0.9776686,0.0002484775,0.008918976,0.00001284047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9651265,0.001375973,0.0297394,0.00009934218,0.00005576195,0.00009887893,0.0005737647,0.0003814553,0.002548871],"genre_scores_gemma":[0.9716917,0.0004469696,0.02048374,0.00006259035,0.00001794371,0.0001084989,0.001298072,0.00007168727,0.005818729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001445244,"threshold_uncertainty_score":0.004834771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03369095921352087,"score_gpt":0.2925217240894682,"score_spread":0.2588307648759473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}