{"id":"W1537729091","doi":"10.1002/jcp.24603","title":"Signals Controlling Un‐Differentiated States in Embryonic Stem and Cancer Cells: Role of the Phosphatidylinositol 3′ Kinase Pathway","year":2014,"lang":"en","type":"review","venue":"Journal of Cellular Physiology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Wnt signaling pathway; Biology; PI3K/AKT/mTOR pathway; Cell biology; Signal transduction; Stem cell; Protein kinase B; Hippo signaling pathway; PTEN; Hes3 signaling axis; Embryonic stem cell; Cancer stem cell; Cancer research; Genetics; Notch signaling pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421116,0.0003508973,0.000410967,0.0006473837,0.0001420771,0.0007623462,0.0003217538,0.0004543999,0.0006607617],"category_scores_gemma":[0.00009393517,0.0001323195,0.000298596,0.0006517491,0.0002362595,0.0006174354,0.0003072075,0.0006032147,0.0004586145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004764512,"about_ca_system_score_gemma":0.0003528407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003985949,"about_ca_topic_score_gemma":0.0003889367,"domain_scores_codex":[0.9998966,0.0000140906,0.00001585417,0.00002125048,0.00003279126,0.00001932514],"domain_scores_gemma":[0.999962,0.00001058949,0.00001130814,0.000001630512,0.000009309977,0.000005230543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002204984,0.0000639182,0.0006982317,0.01038693,0.00008556464,0.001824578,0.0003691941,0.001209318,0.5306405,0.01415679,0.003520927,0.4368236],"study_design_scores_gemma":[0.00002932169,0.0003672244,0.008972104,0.0009269979,0.0002155632,0.004283612,0.0003065615,0.0008007219,0.2779154,0.005519099,0.7005953,0.00006803994],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0224486,0.9650854,0.003900889,0.0003232546,0.0002466444,0.00001889959,0.0002137809,0.00006344679,0.007699142],"genre_scores_gemma":[0.09900489,0.8928851,0.002380138,0.0003538218,0.0001808493,0.00003197122,0.0004741038,0.00001599768,0.004673186],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0007623462,"threshold_uncertainty_score":0.003456891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01316636333260907,"score_gpt":0.267346880466495,"score_spread":0.2541805171338859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}