{"id":"W1538224607","doi":"10.4049/jimmunol.1403016","title":"SAMHD1 Degradation Enhances Active Suppression of Dendritic Cell Maturation by HIV-1","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Universiteit van Amsterdam; School of Medicine, New York University; York University; Aids Fonds","keywords":"SAMHD1; Immune system; Dendritic cell; Biology; Human immunodeficiency virus (HIV); Immunity; Cell biology; Immunology; Virology; Reverse transcriptase; Genetics; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002043968,0.0001982848,0.0002891479,0.0001417115,0.0001383786,0.0003373071,0.0001576276,0.0002161387,0.001327814],"category_scores_gemma":[0.000169283,0.000129933,0.0001633251,0.00009781562,0.0001990079,0.0001743382,0.0001961028,0.0005314202,0.0003003963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001938162,"about_ca_system_score_gemma":0.0001813019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002829476,"about_ca_topic_score_gemma":0.0003721982,"domain_scores_codex":[0.9998331,0.00004706016,0.00001580705,0.0000226182,0.00002791841,0.00005339118],"domain_scores_gemma":[0.9998634,0.00004009758,0.00002615662,0.00002016977,0.00001318898,0.0000370069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002874366,0.0000563973,0.0001522149,0.0000307221,0.000004165802,0.00002813935,0.000009509353,0.00005037312,0.9985225,0.00005873459,0.00003543695,0.0007644667],"study_design_scores_gemma":[0.00001626172,0.0002876338,0.003443274,0.000004008777,0.000007611073,0.0001108618,0.00001328329,0.0007059065,0.9943668,0.00003039666,0.001011292,0.000002770503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965605,0.001571727,0.0007622265,0.00006116668,0.00002502934,0.0000134306,0.0001643743,0.00003551848,0.0008059716],"genre_scores_gemma":[0.9979286,0.0003942971,0.0005327477,0.0000299852,0.000008796485,0.00001035431,0.0002375285,0.000008915033,0.0008486243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001327814,"threshold_uncertainty_score":0.004441977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227966946300691,"score_gpt":0.2435963978826421,"score_spread":0.2313167284196352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}