{"id":"W1538330154","doi":"10.1158/1538-7445.sabcs14-ot3-1-06","title":"Abstract OT3-1-06: A phase 2 single-arm study to evaluate the clinical activity, safety and tolerability of enzalutamide (ENZA) with trastuzumab in patients with advanced human growth factor receptor 2 (HER2)-positive breast cancer","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Trastuzumab; Tolerability; Medicine; Enzalutamide; Oncology; Internal medicine; Clinical endpoint; Metastatic breast cancer; Cancer; Breast cancer; Clinical trial; Androgen receptor; Adverse effect; Prostate cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002060619,0.0004077154,0.001014117,0.0002435474,0.0002056344,0.00004394233,0.0003422486,0.00009705918,0.0002337357],"category_scores_gemma":[0.0002549942,0.0002528467,0.0000665676,0.0009807236,0.0009517347,0.0003805351,0.000197915,0.001147692,0.000004263567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002156717,"about_ca_system_score_gemma":0.001327965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002844161,"about_ca_topic_score_gemma":0.004938599,"domain_scores_codex":[0.994768,0.0007864457,0.0007085804,0.00101157,0.001930302,0.0007951112],"domain_scores_gemma":[0.9956998,0.0005198229,0.0002239915,0.0007240498,0.002237852,0.0005945475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1038021,0.01297101,0.7276486,0.0001572419,0.0004834588,0.00001885123,0.008669234,0.0001410642,0.006717322,0.000006033107,0.0000512788,0.1393339],"study_design_scores_gemma":[0.02786697,0.01604348,0.9485651,0.0007108848,0.00007597226,0.000004544898,0.002487569,0.000005580057,0.003764868,0.00003135161,0.0001425999,0.0003011369],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928631,0.0002896975,0.00003868423,0.001192534,0.00007620041,0.004762527,0.0006457721,0.00003485335,0.00009659462],"genre_scores_gemma":[0.9988544,0.00004375173,0.0001231085,0.0001013392,0.0001631448,0.000565102,0.00001839501,0.00008427683,0.00004650036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2209165,"threshold_uncertainty_score":0.9999924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1184638961843083,"score_gpt":0.4699036391384115,"score_spread":0.3514397429541033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}