{"id":"W1538691949","doi":"10.1002/pd.4532","title":"Current controversies in prenatal diagnosis 4: pre-conception expanded carrier screening should replace all current prenatal screening for specific single gene disorders","year":2014,"lang":"en","type":"article","venue":"Prenatal Diagnosis","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Position statement; Prenatal diagnosis; Medicine; Carrier testing; Prenatal screening; Diagnostic test; Ethnic group; Family medicine; Pediatrics; Pregnancy; Genetics; Fetus; Political science; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04692943,0.0007583292,0.001608596,0.001942933,0.003355396,0.004820103,0.004683638,0.01693145,0.008251416],"category_scores_gemma":[0.1099356,0.0005950636,0.001191061,0.001579374,0.01591252,0.01249258,0.003660026,0.02289813,0.003919321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004084189,"about_ca_system_score_gemma":0.01116107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008414246,"about_ca_topic_score_gemma":0.008703379,"domain_scores_codex":[0.985949,0.005128551,0.002121483,0.001849413,0.004278217,0.0006732657],"domain_scores_gemma":[0.8668805,0.103344,0.004858183,0.002320013,0.01807684,0.004520332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000369981,0.0000954959,0.002668408,0.003650989,0.0001517594,0.0006888323,0.001680384,0.0002657186,0.0006105199,0.08614941,0.455634,0.4480345],"study_design_scores_gemma":[0.0001217113,0.0001620472,0.003412086,0.01353242,0.0002802549,0.002123756,0.004615175,0.0004374783,0.0004953681,0.1422835,0.832385,0.0001512034],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0003726777,0.08399589,0.0006558687,0.9028613,0.0103269,0.000007330957,0.00004903517,0.00003462505,0.001696245],"genre_scores_gemma":[0.03085234,0.2542095,0.006031239,0.6337903,0.07258046,0.00005941088,0.0001841869,0.0001156536,0.002176971],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04692943,"threshold_uncertainty_score":0.2481895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05404905231161106,"score_gpt":0.3424725033672845,"score_spread":0.2884234510556734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}