{"id":"W1538840287","doi":"10.1111/j.1471-4159.2011.07230.x","title":"Role of prostaglandin E2 in the synthesis of the pro‐inflammatory cytokine interleukin‐6 in primary sensory neurons: an <i>in vivo</i> and <i>in vitro</i> study","year":2011,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Dorsal root ganglion; Sciatic nerve; Peripheral nerve injury; Prostaglandin E2; Protein kinase A; Prostaglandin E2 receptor; Medicine; Nociception; MAPK/ERK pathway; Nerve injury; Receptor; Neuropathic pain; Cytokine; Internal medicine; Endocrinology; Cell biology; Signal transduction; Kinase; Pharmacology; Neuroscience; Biology; Anesthesia; Sensory system; Agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002547156,0.0003202577,0.0003439911,0.0001903046,0.0001642861,0.0003078657,0.0001836218,0.0003260078,0.0009840272],"category_scores_gemma":[0.0001158815,0.000128238,0.0003794314,0.0001337517,0.0003004771,0.0003561429,0.0001357652,0.00058268,0.0003465753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002407287,"about_ca_system_score_gemma":0.0001964764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003592382,"about_ca_topic_score_gemma":0.0005502279,"domain_scores_codex":[0.99991,0.00002023385,0.00001066574,0.00001684463,0.00001591318,0.0000263674],"domain_scores_gemma":[0.9999002,0.00002955468,0.00001524852,0.00001023043,0.00001758534,0.00002705853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003017018,0.00005474602,0.0002025799,0.0001801261,0.000004964952,0.000153165,0.00001678971,0.00004190272,0.9978274,0.00005638369,0.00001755702,0.001142672],"study_design_scores_gemma":[0.00005346457,0.002950628,0.009880374,0.00002185873,0.00008355417,0.0008365571,0.0001198306,0.0005520895,0.9831597,0.0001215896,0.002211255,0.000008990248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9659473,0.02359849,0.007025515,0.0002073957,0.0001384606,0.00008650192,0.0003706485,0.00003637197,0.002589361],"genre_scores_gemma":[0.974475,0.01685154,0.005458578,0.0001765926,0.0001638027,0.00008835051,0.0003762507,0.000009743329,0.002400208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009840272,"threshold_uncertainty_score":0.003291845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01514199915989497,"score_gpt":0.2324066541292257,"score_spread":0.2172646549693307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}