{"id":"W1538903365","doi":"10.1111/j.1742-4658.2007.05797.x","title":"Role of receptor‐mediated endocytosis, endosomal acidification and cathepsin D in cholera toxin cytotoxicity","year":2007,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut National de la Santé et de la Recherche Médicale; McGill University","keywords":"Cholera toxin; Endosome; Bafilomycin; Endocytosis; ADP-ribosylation; Biology; Pepstatin; Cathepsin B; Cathepsin D; Biochemistry; Cell biology; Molecular biology; Intracellular; Receptor; Protease; NAD+ kinase; Microbiology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002894519,0.0004468407,0.0004513364,0.0003203936,0.0001913787,0.000537099,0.0001929884,0.000602869,0.0004845139],"category_scores_gemma":[0.0002154108,0.0001868914,0.0003524413,0.0001511716,0.0005212381,0.0004369115,0.0004597431,0.0003747292,0.0001659992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001034325,"about_ca_system_score_gemma":0.000472733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001041012,"about_ca_topic_score_gemma":0.000668308,"domain_scores_codex":[0.9998229,0.00003916045,0.0000189868,0.00002724795,0.00003454497,0.0000571768],"domain_scores_gemma":[0.9998702,0.00003436188,0.00003629172,0.00001626754,0.00001437189,0.00002848091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007449992,0.00003127448,0.001284277,0.0001564977,0.00001403689,0.0004835848,0.00003884044,0.000286435,0.9923742,0.0007727331,0.00002968396,0.003783321],"study_design_scores_gemma":[0.00008913667,0.00066701,0.02296599,0.00002508412,0.00005750712,0.001845374,0.0001272724,0.00355357,0.96704,0.0006426346,0.002958185,0.00002824744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780577,0.01383312,0.005628601,0.0002200783,0.00003019568,0.00005587385,0.000150734,0.00006058175,0.001963146],"genre_scores_gemma":[0.9951873,0.002572295,0.001100017,0.00004463155,0.000008189179,0.00001946549,0.00005595707,0.000006217689,0.001005873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001041012,"threshold_uncertainty_score":0.007504523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007688446487592101,"score_gpt":0.2447774776217461,"score_spread":0.237089031134154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}