{"id":"W1538903365","doi":"10.1111/j.1742-4658.2007.05797.x","title":"Role of receptor‐mediated endocytosis, endosomal acidification and cathepsin D in cholera toxin cytotoxicity","year":2007,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut National de la Santé et de la Recherche Médicale; McGill University","keywords":"Cholera toxin; Endosome; Bafilomycin; Endocytosis; ADP-ribosylation; Biology; Pepstatin; Cathepsin B; Cathepsin D; Biochemistry; Cell biology; Molecular biology; Intracellular; Receptor; Protease; NAD+ kinase; Microbiology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003373999,0.0001079394,0.0001373876,0.00008663232,0.00004746133,0.00001669373,0.0001101491,0.0001361388,0.00003853891],"category_scores_gemma":[0.00007281914,0.00009487538,0.00005087981,0.00009077439,0.00005335236,0.000008437869,0.00003310035,0.0001881719,0.000002193441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001995215,"about_ca_system_score_gemma":0.00005296955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001660513,"about_ca_topic_score_gemma":0.00003690648,"domain_scores_codex":[0.9991586,0.00004256995,0.0002975198,0.0001606411,0.0001274386,0.0002132444],"domain_scores_gemma":[0.9995479,0.0000132613,0.0001456249,0.0001297317,0.00006294892,0.0001005434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001306808,0.00005452735,0.02216465,0.000005244549,0.00001021119,0.000002737934,0.0002042286,0.000001883784,0.9736208,0.000009007852,0.00003549559,0.003760542],"study_design_scores_gemma":[0.0007369287,0.0001225494,0.1112454,0.00001219935,0.000008129838,0.0001282464,0.0001317176,0.000002220439,0.8837739,0.000009081444,0.0037407,0.00008894345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990061,0.00037355,0.00007640669,0.00006084389,0.0001144595,0.00009839434,0.00001453451,0.00000366538,0.0002520766],"genre_scores_gemma":[0.9987108,0.0002774253,0.0005135352,0.0000654574,0.0003330449,0.000002488772,0.00003705025,0.00001098328,0.00004926002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08984694,"threshold_uncertainty_score":0.3868906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007688446487592101,"score_gpt":0.2447774776217461,"score_spread":0.237089031134154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}