{"id":"W1539084053","doi":"10.1111/j.1365-2125.2010.03857.x","title":"Pharmacokinetic and pharmacodynamic comparison of hydrofluoroalkane and chlorofluorocarbon formulations of budesonide","year":2010,"lang":"en","type":"article","venue":"British Journal of Clinical Pharmacology","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chlorofluorocarbon; Inhaler; Metered-dose inhaler; Crossover study; Pharmacokinetics; Budesonide; Bioavailability; Pharmacodynamics; Pharmacology; Medicine; Anesthesia; Chemistry; Asthma; Inhalation; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001147751,0.000127715,0.0009693351,0.0001811013,0.00005441239,0.00000718862,0.0001066446,0.0001889622,0.0004100532],"category_scores_gemma":[0.0003144844,0.0001284562,0.0002004582,0.0001272205,0.0005750449,0.0001257199,0.00005764994,0.001084985,0.000001439078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008652246,"about_ca_system_score_gemma":0.0001669458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000140264,"about_ca_topic_score_gemma":0.000009376949,"domain_scores_codex":[0.9972404,0.000181854,0.001963156,0.0001686691,0.0002666427,0.0001792866],"domain_scores_gemma":[0.9973832,0.0006274724,0.001128117,0.000072941,0.0004708427,0.0003174355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001099625,0.001072197,0.06930858,0.0002005109,0.0003665742,0.0001857686,0.0001090853,0.00003702933,0.6414493,0.00003928234,0.001233443,0.2848987],"study_design_scores_gemma":[0.05336602,0.004465625,0.5557627,0.0007195727,0.004526602,0.01057535,0.0002174229,0.04373917,0.3023531,0.0002556542,0.02338033,0.00063844],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943023,0.002906251,0.00007995628,0.0004550956,0.001408726,0.0002386439,0.00001285337,0.000007149177,0.0005889725],"genre_scores_gemma":[0.9950046,0.002807309,0.0009331243,0.0005227167,0.0006513602,0.000001846902,0.000003130756,0.0000173343,0.00005858502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4864541,"threshold_uncertainty_score":0.5238293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0337278603077398,"score_gpt":0.4276013280692031,"score_spread":0.3938734677614634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}