{"id":"W1540273720","doi":"10.4049/jimmunol.1400885","title":"DOCK2 and DOCK5 Act Additively in Neutrophils To Regulate Chemotaxis, Superoxide Production, and Extracellular Trap Formation","year":2014,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Neutrophil extracellular traps; Chemotaxis; Cell biology; Guanine nucleotide exchange factor; Rac GTP-Binding Proteins; Innate immune system; Superoxide; Small GTPase; Extracellular; Inflammation; Biology; Chemistry; GTPase; Immunology; Signal transduction; Immune system; Receptor; RAC1; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002519003,0.000391376,0.0004255301,0.0002612117,0.0001782456,0.0005923251,0.0003045694,0.0003407744,0.001082902],"category_scores_gemma":[0.0001942926,0.0001885016,0.0003950203,0.0001110515,0.0002983234,0.000323233,0.0005543669,0.0004974401,0.0002472378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005037152,"about_ca_system_score_gemma":0.000244257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006186276,"about_ca_topic_score_gemma":0.001196743,"domain_scores_codex":[0.9994916,0.00007360389,0.00005385551,0.00009857577,0.0001680315,0.0001143954],"domain_scores_gemma":[0.9998978,0.000011369,0.00002319814,0.00001547846,0.00001175753,0.00004027453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003489186,0.00002605345,0.0005413566,0.00006438613,0.00001360318,0.0001122427,0.000008369827,0.0001404051,0.9969839,0.0001954579,0.00007458778,0.001490653],"study_design_scores_gemma":[0.00005899859,0.0003704131,0.01008517,0.000007514046,0.00004344384,0.0005300736,0.00003907319,0.001971907,0.983469,0.00006930676,0.003344235,0.00001081451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98243,0.006549054,0.008273366,0.0001688191,0.0000845492,0.0000405434,0.0004233471,0.00009842603,0.001931889],"genre_scores_gemma":[0.9950988,0.0006904317,0.002014404,0.00006554821,0.000008451039,0.00002629521,0.000347646,0.00001005372,0.001738426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001082902,"threshold_uncertainty_score":0.003654778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009594664122336314,"score_gpt":0.21077186088334,"score_spread":0.2011771967610037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}