{"id":"W1540752964","doi":"10.1007/s12094-015-1379-7","title":"Familial hematological malignancies: ASXL1 gene investigation","year":2015,"lang":"en","type":"article","venue":"Clinical & Translational Oncology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; Société Française d'Hématologie; Institut National Du Cancer; Ministère de l'Enseignement Supérieur et de la Recherche Scientifique","keywords":"Gene; Germline; In silico; Missense mutation; Genetics; CEBPA; Germline mutation; Medicine; Candidate gene; Phenotype; Biology; Mutation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001659884,0.0001797744,0.0006789691,0.00009708943,0.0000621322,0.00001052689,0.0001789462,0.0006588595,0.0002388495],"category_scores_gemma":[0.002227069,0.0001439076,0.0002263148,0.0002779791,0.0008710822,0.00009875523,0.00004765512,0.0005683009,0.0006578098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003806098,"about_ca_system_score_gemma":0.004678278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001888294,"about_ca_topic_score_gemma":0.00001463106,"domain_scores_codex":[0.996959,0.0004102239,0.001047306,0.0004887249,0.0007047049,0.0003899816],"domain_scores_gemma":[0.9962883,0.002020934,0.0001378493,0.0002590602,0.0004852606,0.0008086137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0137689,0.004295172,0.7421835,0.0002181077,0.0008651594,0.003129262,0.001840116,0.0005071535,0.01164862,0.04863949,0.1265563,0.0463482],"study_design_scores_gemma":[0.05269361,0.01189945,0.5580694,0.0001476953,0.0006332949,0.003297169,0.0003744898,0.02697252,0.002062076,0.05409802,0.2888524,0.000899901],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9504713,0.0002484464,0.009486869,0.02725656,0.0007878437,0.0006564101,0.0000280695,0.000147199,0.01091735],"genre_scores_gemma":[0.9626245,0.00004782334,0.02934469,0.005810859,0.001160473,0.00005374734,0.0002444481,0.00002630933,0.0006871424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1841141,"threshold_uncertainty_score":0.8455033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1999885232251881,"score_gpt":0.4443350567742201,"score_spread":0.244346533549032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}