{"id":"W1541024168","doi":"10.1074/jbc.m006104200","title":"Dantrolene Inhibition of Ryanodine Receptor Ca2+Release Channels","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":323,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; University of Minnesota; American Heart Association","keywords":"Ryanodine receptor; Dantrolene; Malignant hyperthermia; Chemistry; Receptor; Pharmacology; Calcium; Medicine; Anesthesia; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000112305,0.0003928366,0.0003301011,0.00010728,0.0001104069,0.0002327942,0.000191122,0.0002072927,0.0009885026],"category_scores_gemma":[0.0001438985,0.00009086511,0.0003111078,0.00008222071,0.0002051657,0.0001873051,0.0001758544,0.0004193184,0.0002191094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002078777,"about_ca_system_score_gemma":0.0001993406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006050362,"about_ca_topic_score_gemma":0.001364437,"domain_scores_codex":[0.9998866,0.00001916041,0.00001683074,0.00002255152,0.00002440025,0.00003039479],"domain_scores_gemma":[0.9999295,0.00002112393,0.00001970939,0.00001243838,0.000007382018,0.000009836418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008572379,0.00001877357,0.00006906775,0.0000386369,0.000006639017,0.00003436486,0.00001165175,0.00004595839,0.9986046,0.00008980658,0.00002300703,0.0009718045],"study_design_scores_gemma":[0.00002821482,0.0003634529,0.003689605,0.000005419663,0.0000131161,0.0001493545,0.00001804595,0.0006352625,0.9937161,0.00003643897,0.001340928,0.00000414345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934416,0.002629939,0.001366826,0.00008850711,0.0000334538,0.0000360212,0.0002629574,0.00007100822,0.00206977],"genre_scores_gemma":[0.9933999,0.002448168,0.001251603,0.00004721329,0.000008940639,0.00005155066,0.0003285278,0.00001495573,0.002449333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009885026,"threshold_uncertainty_score":0.003306925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01939194048686747,"score_gpt":0.243056027898632,"score_spread":0.2236640874117645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}