{"id":"W1541044354","doi":"10.4049/jimmunol.167.11.6188","title":"TCR/Self-Antigen Interactions Drive Double-Negative T Cell Peripheral Expansion and Differentiation into Suppressor Cells","year":2001,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biology; Peripheral tolerance; CD8; Cytotoxic T cell; Cell biology; T-cell receptor; T cell; Immunology; Clonal deletion; Interleukin 21; Cytolysis; Antigen; In vitro; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009374304,0.0002241593,0.0001222754,0.0001375198,0.00007735746,0.0002325105,0.0001148452,0.0001146891,0.001096525],"category_scores_gemma":[0.0001282329,0.0001136409,0.00006626071,0.00007685475,0.0001475163,0.0001062303,0.0001511438,0.0003486222,0.0004947914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001107642,"about_ca_system_score_gemma":0.00009118262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007547185,"about_ca_topic_score_gemma":0.000202751,"domain_scores_codex":[0.999886,0.00001657733,0.000008909175,0.00002455214,0.00002749049,0.00003630486],"domain_scores_gemma":[0.9998509,0.00002059121,0.00003842663,0.00002655356,0.00001018527,0.00005343267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004847959,0.00001577408,0.0002497024,0.000008650276,8.643979e-7,0.00004491354,0.000007766623,0.00002943309,0.9985454,0.00006114081,0.00001864961,0.0009692235],"study_design_scores_gemma":[0.00004495786,0.0004348231,0.006547363,0.000006657182,0.00001332995,0.001148156,0.00002806089,0.001715124,0.9868736,0.0001312012,0.00305385,0.00000288385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967629,0.0003087425,0.001436361,0.00001673976,0.000009383524,0.000009090513,0.00005326034,0.00008449344,0.001319098],"genre_scores_gemma":[0.9970739,0.0001439498,0.0009087555,0.0000159146,0.000008721935,0.000008316427,0.000143069,0.00002119565,0.001676247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001096525,"threshold_uncertainty_score":0.003668189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009703478665308424,"score_gpt":0.2323109408907844,"score_spread":0.222607462225476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}