{"id":"W1541543070","doi":"10.1186/ar1405","title":"Systemic lupus erythematosus is characterized by faulty B-cell tolerance in the germinal centers","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"Germinal center; Immunology; Antibody; Antigen; Population; Autoantibody; B cell; Biology; Epitope; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003524339,0.0003261503,0.0007265192,0.0005074505,0.0003177802,0.0002013721,0.0008213151,0.0002395537,0.0002336021],"category_scores_gemma":[0.0002100988,0.0002434445,0.0002022014,0.001316783,0.0004584177,0.0002333696,0.0001967877,0.001489043,0.001219022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005893721,"about_ca_system_score_gemma":0.0004972109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004537901,"about_ca_topic_score_gemma":0.00006448207,"domain_scores_codex":[0.9930598,0.0007801954,0.0008215673,0.000814145,0.002888891,0.001635386],"domain_scores_gemma":[0.9974343,0.0004615237,0.000105992,0.001189229,0.0004438446,0.0003651023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"case_report","study_design_scores_codex":[0.004379483,0.00547368,0.3782643,0.009536529,0.0001915745,0.01489976,0.05395826,0.00001134207,0.4152346,0.0008910813,0.08963287,0.02752656],"study_design_scores_gemma":[0.1200321,0.004219629,0.004243791,0.03181552,0.00005695092,0.5574052,0.05590824,0.0004347891,0.0663818,0.001457603,0.1557981,0.002246239],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771026,0.01059016,0.00005729853,0.003544863,0.0002237922,0.003227301,0.000071079,0.0000698805,0.005112974],"genre_scores_gemma":[0.9896623,0.005147871,0.00008883743,0.0005209084,0.0002615317,0.0009606181,0.0000503103,0.00007427143,0.003233372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5425054,"threshold_uncertainty_score":0.9995586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03379190697151775,"score_gpt":0.3319570793518591,"score_spread":0.2981651723803414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}