{"id":"W1541543070","doi":"10.1186/ar1405","title":"Systemic lupus erythematosus is characterized by faulty B-cell tolerance in the germinal centers","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"Germinal center; Immunology; Antibody; Antigen; Population; Autoantibody; B cell; Biology; Epitope; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003847178,0.0004975114,0.0003619834,0.001001816,0.0003216257,0.000578985,0.0003626098,0.0004256443,0.004110156],"category_scores_gemma":[0.0007480807,0.0001167038,0.0001606999,0.000867816,0.0004088296,0.0003351964,0.0003652255,0.0003130313,0.0008028969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002177839,"about_ca_system_score_gemma":0.0001375335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000343454,"about_ca_topic_score_gemma":0.0002326633,"domain_scores_codex":[0.999651,0.0001140945,0.00004422761,0.0000819347,0.00005542858,0.00005335529],"domain_scores_gemma":[0.9995511,0.00007811208,0.0002453775,0.00002664355,0.00004073981,0.00005803811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001925336,0.0005997074,0.6594465,0.001180729,0.0003031498,0.05852285,0.001266984,0.000460462,0.1200467,0.004152297,0.00843526,0.14366],"study_design_scores_gemma":[0.0002011982,0.0009523164,0.6989166,0.0003823061,0.0002201319,0.2499969,0.0007019006,0.0005228891,0.009992252,0.003768139,0.03431456,0.00003092303],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692141,0.01242497,0.002101685,0.0006954336,0.0001006778,0.0000728821,0.0004469499,0.0002306435,0.01471268],"genre_scores_gemma":[0.9960691,0.001556385,0.0008536546,0.0002571004,0.0001066542,0.00002114904,0.0002558447,0.00001307175,0.0008670746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004110156,"threshold_uncertainty_score":0.01374984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03379190697151775,"score_gpt":0.3319570793518591,"score_spread":0.2981651723803414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}