{"id":"W1541887683","doi":"10.1002/ccd.24555","title":"High‐dose plasmid‐mediated VEGF gene transfer is safe in patients with severe ischemic heart disease (Genesis‐I). A phase I, open‐label, two‐year follow‐up trial","year":2012,"lang":"en","type":"article","venue":"Catheterization and Cardiovascular Interventions","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Agencia Nacional de Promoción Científica y Tecnológica","keywords":"Medicine; Coronary artery disease; Cardiology; Ejection fraction; Internal medicine; Myocardial infarction; Revascularization; Angina; Myocardial perfusion imaging; Perfusion; Adverse effect; Ischemia; Unstable angina; Canadian Cardiovascular Society; Surgery; Heart failure","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00130063,0.0009259255,0.001302887,0.0002341563,0.0002401867,0.0007216907,0.0003587041,0.001296304,0.001871711],"category_scores_gemma":[0.0006871294,0.0002959365,0.0008874997,0.000208415,0.0008217745,0.0006391457,0.0002161729,0.001671774,0.0004253044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003576611,"about_ca_system_score_gemma":0.0004675934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002083705,"about_ca_topic_score_gemma":0.0003385533,"domain_scores_codex":[0.9996547,0.0001737276,0.00001649316,0.00005626538,0.00003211777,0.00006677602],"domain_scores_gemma":[0.9994941,0.0001377733,0.0001257992,0.00005312141,0.00002741898,0.0001617492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.763651,0.04391335,0.009131924,0.0008187541,0.001394467,0.0003156103,0.000266925,0.001139193,0.07380688,0.0002865003,0.001811012,0.1034643],"study_design_scores_gemma":[0.5436047,0.4398393,0.01002686,0.00002315863,0.0003415514,0.0001947677,0.00002508017,0.000575233,0.004253397,0.00009767756,0.0009993124,0.00001882446],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996378,0.001709614,0.0004616288,0.0002282884,0.00006640327,0.0003871789,0.0001936243,0.00004967469,0.000525579],"genre_scores_gemma":[0.9952633,0.001025539,0.0007931866,0.0005447056,0.0001618427,0.0007086723,0.0007166564,0.00001432354,0.0007716769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001871711,"threshold_uncertainty_score":0.006878495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02466561971587828,"score_gpt":0.2824038805139471,"score_spread":0.2577382607980688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}