{"id":"W1542125043","doi":"10.1016/s0065-7743(07)42008-5","title":"Chapter 8 Cathepsin K Inhibitors","year":2007,"lang":"en","type":"book-chapter","venue":"Annual reports in medicinal chemistry","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Cathepsin K; Osteoclast; Bone resorption; Cathepsin; Proteases; Chemistry; Osteopetrosis; Genetically modified mouse; Bone remodeling; Bone disease; Osteoporosis; Molecular biology; In vitro; Internal medicine; Endocrinology; Transgene; Biology; Enzyme; Medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001388645,0.0009614276,0.0005238084,0.0009884208,0.0002742595,0.0008977178,0.0006491434,0.0007225399,0.05004829],"category_scores_gemma":[0.0001624546,0.0003265298,0.0004096649,0.0006679412,0.0001708821,0.0007144814,0.0005630154,0.001348812,0.02990648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005513816,"about_ca_system_score_gemma":0.0005520007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004792819,"about_ca_topic_score_gemma":0.001400667,"domain_scores_codex":[0.9998746,0.000007807103,0.000006120716,0.00002103163,0.00006862553,0.00002177738],"domain_scores_gemma":[0.9999652,0.000006094941,0.000005085957,0.000003113443,0.000009525853,0.00001094781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002548316,0.0002649538,0.00006779993,0.002224287,0.00004158566,0.0002165877,0.00006137774,0.0006099227,0.03744791,0.008321592,0.3878362,0.562653],"study_design_scores_gemma":[0.00002323323,0.0001072877,0.0001277635,0.0001466936,0.00001491148,0.0003485086,0.000006585472,0.00006073013,0.005854312,0.001070594,0.9922327,0.000006670596],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005077124,0.5604798,0.007672841,0.002984568,0.008288308,0.0002461001,0.001744529,0.001209746,0.412297],"genre_scores_gemma":[0.01240522,0.3029913,0.003017394,0.002399827,0.001711407,0.0001981323,0.002122373,0.0001629649,0.6749913],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.05004829,"threshold_uncertainty_score":0.1674282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01139803953032533,"score_gpt":0.2599243349790286,"score_spread":0.2485262954487032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}