{"id":"W1542217606","doi":"10.1111/j.1471-4159.2004.02453.x","title":"Focal dysfunction of the proteasome: a pathogenic factor in a mouse model of amyotrophic lateral sclerosis","year":2004,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"McGill University","keywords":"Amyotrophic lateral sclerosis; Proteasome; Spinal cord; Lumbar Spinal Cord; Genetically modified mouse; Superoxide dismutase; Endocrinology; Biology; Internal medicine; Transgene; Medicine; Oxidative stress; Neuroscience; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002690884,0.001220256,0.0006226497,0.001044071,0.0004320821,0.0004661994,0.0004988406,0.001367429,0.00172845],"category_scores_gemma":[0.000141598,0.0004022622,0.0004925365,0.0003647208,0.0005286449,0.0005040327,0.000396037,0.001389592,0.0007231316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006021176,"about_ca_system_score_gemma":0.0003323329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000669044,"about_ca_topic_score_gemma":0.001099639,"domain_scores_codex":[0.9996672,0.00003930636,0.0000391243,0.00009230889,0.00009631387,0.00006582138],"domain_scores_gemma":[0.9997603,0.00001447559,0.0000727735,0.0000217917,0.00002051209,0.0001100805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003159697,0.0001752107,0.0001923389,0.00004513984,0.00001077621,0.0002722826,0.00002266862,0.00003339898,0.9979249,0.0001036947,0.0000712377,0.0008323228],"study_design_scores_gemma":[0.00028253,0.004486696,0.01636211,0.00008369703,0.0001293672,0.00370102,0.0001065082,0.001531789,0.9665422,0.0004180986,0.006327395,0.00002866052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906552,0.003118213,0.002898659,0.0004004787,0.0001307816,0.000142065,0.0007909833,0.0004256307,0.001438007],"genre_scores_gemma":[0.9841456,0.002342692,0.003212174,0.0002102343,0.00004115813,0.0002820335,0.001082473,0.00007244311,0.008611193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00172845,"threshold_uncertainty_score":0.005782247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04059689944843405,"score_gpt":0.2621301581769388,"score_spread":0.2215332587285048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}