{"id":"W1542253046","doi":"10.3389/fmicb.2015.00755","title":"Beyond phage display: non-traditional applications of the filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffold","year":2015,"lang":"en","type":"review","venue":"Frontiers in Microbiology","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Guelph; Carleton University; National Research Council Canada","funders":"National Research Council Canada","keywords":"Bioconjugation; Filamentous bacteriophage; Bacteriophage; Immunogenicity; Biology; Phage display; Phagemid; Computational biology; Nanotechnology; Immune system; Genetics; Antibody; Escherichia coli; Materials science; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006228568,0.0005531615,0.0007263321,0.0004879199,0.0002809555,0.001148182,0.0004180982,0.0007750412,0.001040234],"category_scores_gemma":[0.0003924875,0.0002158584,0.000362864,0.0004867057,0.0008255446,0.001113442,0.0006329812,0.001193775,0.0007059055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006372544,"about_ca_system_score_gemma":0.0005138007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004081425,"about_ca_topic_score_gemma":0.0004692909,"domain_scores_codex":[0.9997192,0.00008595199,0.00001366634,0.00004573133,0.000100554,0.00003478042],"domain_scores_gemma":[0.9998226,0.0001024884,0.0000157591,0.000009816868,0.00002824596,0.00002113777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000234667,0.000163496,0.0007068221,0.01066466,0.00009242594,0.001104718,0.000805695,0.001232801,0.3833759,0.1011009,0.01511252,0.4854054],"study_design_scores_gemma":[0.00001480094,0.0005017667,0.001078754,0.0008827203,0.00006181892,0.002000035,0.0001877455,0.0009966177,0.07454401,0.01734438,0.9023486,0.00003869001],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01525957,0.9407317,0.02364032,0.00257455,0.001108742,0.00003684365,0.00006310354,0.0001511587,0.01643402],"genre_scores_gemma":[0.08744504,0.8840325,0.01391113,0.001736739,0.001002873,0.00006837614,0.0001043141,0.00004323593,0.01165581],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001148182,"threshold_uncertainty_score":0.004623592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01460299956900612,"score_gpt":0.2610344029450907,"score_spread":0.2464314033760846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}