{"id":"W1542846909","doi":"10.1111/bpa.12188","title":"Thiamine Deficiency‐Mediated Brain Mitochondrial Pathology in<scp>A</scp>laskan<scp>H</scp>uskies with Mutation in<scp><i>SLC19A3.1</i></scp>","year":2014,"lang":"en","type":"article","venue":"Brain Pathology","topic":"Alcoholism and Thiamine Deficiency","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Environmental Health Sciences; National Institutes of Health","keywords":"Thiamine; Thiamine pyrophosphate; Oxidative stress; Endocrinology; Biology; Oxidative phosphorylation; Internal medicine; Mitochondrion; Bioenergetics; Mutation; Chemistry; Biochemistry; Medicine; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008753079,0.0003764846,0.0001944418,0.0003116386,0.0002040507,0.0001938345,0.0001614602,0.0004083922,0.001210956],"category_scores_gemma":[0.0001060698,0.0001481256,0.0003204241,0.0001170118,0.0003829534,0.0001376255,0.0001970959,0.0003149222,0.0002576922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002380192,"about_ca_system_score_gemma":0.0001460963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002506754,"about_ca_topic_score_gemma":0.003481381,"domain_scores_codex":[0.9999557,0.000006087557,0.000005407306,0.00001384357,0.00001047847,0.000008600944],"domain_scores_gemma":[0.9999126,0.00001242177,0.00003916486,0.000003979127,0.000006029829,0.00002567397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007963906,0.0002261827,0.02210366,0.0001649357,0.0001791949,0.0162694,0.0003034535,0.001330422,0.9549437,0.0004085809,0.0002661106,0.003007985],"study_design_scores_gemma":[0.0003146269,0.003472574,0.5293458,0.00009495085,0.0005113959,0.06800826,0.00096037,0.02973142,0.3606798,0.0011261,0.005619267,0.0001353162],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993243,0.00004981982,0.0003062437,0.00001454441,0.000003016408,0.000005672868,0.0001249868,0.00002188414,0.000149458],"genre_scores_gemma":[0.9987884,0.00009235678,0.0004915587,0.00001581692,0.000002115481,0.000008557126,0.0002272612,0.000009477964,0.0003644702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002506754,"threshold_uncertainty_score":0.00498426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101393184779479,"score_gpt":0.2452874908538584,"score_spread":0.2351481723759105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}