{"id":"W1543001415","doi":"10.1155/2015/708306","title":"Disruption in the Blood-Brain Barrier: The Missing Link between Brain and Body Inflammation in Bipolar Disorder?","year":2015,"lang":"en","type":"review","venue":"Neural Plasticity","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University","funders":"Ontario Ministry of Research and Innovation; Ontario Ministry of Research, Innovation and Science","keywords":"Blood–brain barrier; Proinflammatory cytokine; Central nervous system; Inflammation; Neuroscience; Neuroinflammation; Myelin; Multiple sclerosis; Oxidative stress; Medicine; Biology; Immunology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003462297,0.0006426604,0.00117438,0.001530207,0.0002899145,0.0008460105,0.0007024084,0.001106569,0.002580283],"category_scores_gemma":[0.0005105552,0.00019356,0.0003251146,0.001686678,0.0005833855,0.001280343,0.0005395655,0.001317571,0.001367322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006438939,"about_ca_system_score_gemma":0.0009868686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001903401,"about_ca_topic_score_gemma":0.00361162,"domain_scores_codex":[0.9999052,0.00001597834,0.00002034746,0.00001782434,0.00002921384,0.0000113153],"domain_scores_gemma":[0.999853,0.00005493715,0.000028676,0.00000455377,0.00003857931,0.00002007115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0001014515,0.00003450044,0.0003057752,0.01920569,0.00008865861,0.0003677703,0.00009419792,0.0001590792,0.001157826,0.00387152,0.03135401,0.9432595],"study_design_scores_gemma":[0.00002939793,0.0001136222,0.002943493,0.00893399,0.0002075208,0.004689325,0.0002213103,0.0001020484,0.0003835011,0.005610107,0.9767337,0.0000320179],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007033605,0.9991148,0.00003635977,0.0003334698,0.0001044757,0.000001130464,0.000008837388,0.00000295541,0.0003276805],"genre_scores_gemma":[0.0007157248,0.9986628,0.0000737848,0.0001633666,0.0001344895,0.000001861166,0.00001378957,6.819691e-7,0.0002334465],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002580283,"threshold_uncertainty_score":0.008631885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0624091709496349,"score_gpt":0.3247535046352533,"score_spread":0.2623443336856184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}