{"id":"W1543052164","doi":"10.1038/mt.2015.119","title":"T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research","keywords":"NKG2D; Chimeric antigen receptor; Immunotherapy; Receptor; Adoptive cell transfer; Cancer research; Antigen; Biology; T cell; Cytotoxic T cell; Immunology; Cell biology; Molecular biology; In vitro; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003560187,0.0009170312,0.0004752281,0.0004858931,0.0002191566,0.0005049249,0.0004069432,0.001053527,0.001206732],"category_scores_gemma":[0.0001924043,0.0002967805,0.0003924349,0.000204975,0.0004583328,0.000319228,0.0002630913,0.001569283,0.0007541045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004174715,"about_ca_system_score_gemma":0.0003184124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006644087,"about_ca_topic_score_gemma":0.0006119005,"domain_scores_codex":[0.999473,0.00009647993,0.00004998844,0.0001186134,0.0001213251,0.00014053],"domain_scores_gemma":[0.99978,0.00004555742,0.00007030131,0.00003582499,0.00002050072,0.00004783282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001971233,0.00008402225,0.0001065405,0.00003788491,0.000009363535,0.00005791067,0.00002309629,0.0002066178,0.9978548,0.0002219943,0.0001124614,0.001088239],"study_design_scores_gemma":[0.00008855511,0.0008235381,0.0006546286,0.00001229185,0.00002070885,0.0003520335,0.00001717148,0.001294127,0.9942781,0.00007333206,0.002378211,0.000007216681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808836,0.001759457,0.01111143,0.0003318973,0.0001220866,0.0002647665,0.0008806979,0.0005848747,0.004061155],"genre_scores_gemma":[0.9837948,0.001283655,0.00715777,0.0002192938,0.00002466159,0.000356784,0.0009831807,0.0001054102,0.006074524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001206732,"threshold_uncertainty_score":0.004036903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01764675889521441,"score_gpt":0.2753778095718784,"score_spread":0.2577310506766639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}