{"id":"W1543052164","doi":"10.1038/mt.2015.119","title":"T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research","keywords":"NKG2D; Chimeric antigen receptor; Immunotherapy; Receptor; Adoptive cell transfer; Cancer research; Antigen; Biology; T cell; Cytotoxic T cell; Immunology; Cell biology; Molecular biology; In vitro; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006398199,0.0002837069,0.0004269271,0.0002198624,0.00003914499,0.00003617922,0.000208079,0.0001390446,0.0003944121],"category_scores_gemma":[0.00004372585,0.0002262934,0.0001085948,0.0007065831,0.00008826538,0.00006952925,0.00003570832,0.0004397553,0.00005928552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001552024,"about_ca_system_score_gemma":0.0001806469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001803323,"about_ca_topic_score_gemma":0.00001126797,"domain_scores_codex":[0.99797,0.0001213928,0.0002766236,0.0004269577,0.0006488895,0.0005560671],"domain_scores_gemma":[0.9990732,0.00004693438,0.00006309932,0.0003821143,0.0001230251,0.0003116237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00123508,0.0002378512,0.004249416,0.00001617756,0.0001242032,0.0002833422,0.001416746,0.0002782011,0.9871802,0.000006404649,0.0003693817,0.004603029],"study_design_scores_gemma":[0.004307806,0.0008347226,0.001138731,0.0000608346,0.00001006833,0.00004180222,0.000227191,0.0005709243,0.9809734,0.00001510816,0.01153931,0.0002801624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941097,0.001741238,0.001001133,0.0004912284,0.0001616823,0.0006803516,0.000003210121,0.00007893766,0.001732471],"genre_scores_gemma":[0.9958989,0.0003169369,0.001800909,0.0003826602,0.0001403773,0.00003770605,0.00004150874,0.00009942841,0.00128157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01116993,"threshold_uncertainty_score":0.9227979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01764675889521441,"score_gpt":0.2753778095718784,"score_spread":0.2577310506766639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}