{"id":"W1543052543","doi":"10.4049/jimmunol.0901140","title":"MyD88 Adaptor-Like Is Not Essential for TLR2 Signaling and Inhibits Signaling by TLR3","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Biotechnology and Biological Sciences Research Council","keywords":"TLR2; TLR3; TLR4; Signal transducing adaptor protein; Toll-like receptor; Cell biology; Signal transduction; Ligand (biochemistry); Receptor; Chemistry; Innate immune system; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001233845,0.000169911,0.0003895512,0.0002006781,0.0002065649,0.00001708936,0.000272823,0.0002682118,0.00008076912],"category_scores_gemma":[0.0001228335,0.0001228796,0.0001097997,0.0001070605,0.0001725122,0.0001964908,0.00003869557,0.0004888213,0.00001832987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003923465,"about_ca_system_score_gemma":0.0000782884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001788169,"about_ca_topic_score_gemma":0.000001557518,"domain_scores_codex":[0.9983826,0.0004033841,0.0006981483,0.0001206277,0.00004580442,0.0003493879],"domain_scores_gemma":[0.998746,0.0004607957,0.0004719225,0.0001565666,0.000151696,0.00001299532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003191578,0.00005603653,0.00002006192,0.000005581947,0.0001668565,0.000002229976,0.001308168,0.00001587709,0.9847763,0.0001777887,0.001865202,0.008414319],"study_design_scores_gemma":[0.002770462,0.0009809372,0.0005243978,0.00007920803,0.00008543055,0.0005041064,0.0006030612,0.0000148254,0.9829575,0.0004975079,0.01084284,0.0001396747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789482,0.01628732,0.00113834,0.002895862,0.0004734746,0.000200068,0.000006504655,0.00001037656,0.00003985627],"genre_scores_gemma":[0.9978089,0.0009203929,0.0001034037,0.0006843743,0.00006214109,0.000002457781,0.00000938478,0.00001190472,0.000397042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0188607,"threshold_uncertainty_score":0.5010886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00941090005275775,"score_gpt":0.2340065947003946,"score_spread":0.2245956946476368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}