{"id":"W1543052543","doi":"10.4049/jimmunol.0901140","title":"MyD88 Adaptor-Like Is Not Essential for TLR2 Signaling and Inhibits Signaling by TLR3","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Biotechnology and Biological Sciences Research Council","keywords":"TLR2; TLR3; TLR4; Signal transducing adaptor protein; Toll-like receptor; Cell biology; Signal transduction; Ligand (biochemistry); Receptor; Chemistry; Innate immune system; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001634222,0.0003359919,0.0003005229,0.0001560716,0.000149806,0.0003020341,0.000205198,0.0002635847,0.001675195],"category_scores_gemma":[0.000179249,0.0001732489,0.0003848776,0.0001251763,0.0001897527,0.0002203547,0.0003129405,0.0005001785,0.0009773648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002587279,"about_ca_system_score_gemma":0.0001827767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001935949,"about_ca_topic_score_gemma":0.0002770387,"domain_scores_codex":[0.9997162,0.00004854972,0.00002789268,0.00004230186,0.00008055974,0.00008445181],"domain_scores_gemma":[0.9997863,0.00003255403,0.00008093249,0.00003735607,0.00002376814,0.00003909107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009814823,0.00001420943,0.0004244179,0.00002988534,0.000004127839,0.00006039608,0.000006627138,0.00002514837,0.9986505,0.0000356235,0.0000256055,0.0006253475],"study_design_scores_gemma":[0.00002080043,0.000165466,0.01387938,0.000009657538,0.00001070709,0.001099734,0.00003263696,0.0007021872,0.9798783,0.0000406339,0.004154767,0.000005666669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948347,0.001190878,0.002356271,0.00008772228,0.00002637744,0.00002357359,0.0005272118,0.00008720171,0.0008662395],"genre_scores_gemma":[0.9941643,0.0003825375,0.001881555,0.00007868026,0.000009304152,0.00004677045,0.001781685,0.00003500143,0.001620098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001675195,"threshold_uncertainty_score":0.005604088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00941090005275775,"score_gpt":0.2340065947003946,"score_spread":0.2245956946476368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}