{"id":"W1543322656","doi":"10.1002/eji.201444902","title":"Proteasome isoforms exhibit only quantitative differences in cleavage and epitope generation","year":2014,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Biotechnology and Biological Sciences Research Council; Onyx Pharmaceuticals; Berlin Institute of Health; Deutsche Forschungsgemeinschaft; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Royal Society; Leverhulme Trust","keywords":"Biology; Epitope; Gene isoform; Proteasome; Cleavage (geology); Cell biology; Computational biology; Immunology; Biochemistry; Antigen; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008982341,0.0001151236,0.0001891589,0.00009153332,0.00005256636,0.00002497945,0.0001741227,0.00004997021,0.00001143243],"category_scores_gemma":[0.0002680548,0.00009011479,0.00004589219,0.00004947483,0.0001205947,0.00001144133,0.00008236174,0.0001955638,0.00001303566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007220679,"about_ca_system_score_gemma":0.00003763472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003176747,"about_ca_topic_score_gemma":0.00001087971,"domain_scores_codex":[0.9985743,0.0006856822,0.0003522982,0.0001525705,0.00006901183,0.0001661731],"domain_scores_gemma":[0.9994819,0.00001968121,0.000255843,0.000128276,0.00007170983,0.00004256474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001868356,0.00005032697,0.005773254,0.000008695425,0.00004378119,0.00002169624,0.0003508091,0.000003017992,0.9542707,0.0009141031,0.0001377734,0.03823897],"study_design_scores_gemma":[0.00422299,0.01247326,0.3300329,0.0001650195,0.00002817542,0.0009759655,0.0006731697,0.0001702057,0.6229057,0.0005189452,0.0272779,0.0005556693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931608,0.002157896,0.002532509,0.0002191553,0.0001705576,0.00009918617,0.000002231664,0.000003181003,0.001654484],"genre_scores_gemma":[0.9970866,0.0006293796,0.001773454,0.000135185,0.0002353508,0.000001488747,0.000006475698,0.00001585549,0.0001161417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.331365,"threshold_uncertainty_score":0.3674775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02267079692379199,"score_gpt":0.2342768733121733,"score_spread":0.2116060763883812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}