{"id":"W1543322656","doi":"10.1002/eji.201444902","title":"Proteasome isoforms exhibit only quantitative differences in cleavage and epitope generation","year":2014,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Biotechnology and Biological Sciences Research Council; Onyx Pharmaceuticals; Berlin Institute of Health; Deutsche Forschungsgemeinschaft; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Royal Society; Leverhulme Trust","keywords":"Biology; Epitope; Gene isoform; Proteasome; Cleavage (geology); Cell biology; Computational biology; Immunology; Biochemistry; Antigen; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007055867,0.0003408276,0.000243554,0.0002683889,0.0001181895,0.0005634116,0.000189555,0.0002949641,0.001124999],"category_scores_gemma":[0.0006986501,0.0002070898,0.0003148261,0.0002215999,0.0002711911,0.000340079,0.00025143,0.0004541754,0.0004423669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001752389,"about_ca_system_score_gemma":0.0001133603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007550511,"about_ca_topic_score_gemma":0.00009356032,"domain_scores_codex":[0.999332,0.00009331068,0.0001383627,0.0002012827,0.0001465768,0.00008851427],"domain_scores_gemma":[0.9991903,0.0001712192,0.0002635527,0.0001721791,0.0001048356,0.00009791261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003082862,0.0000298356,0.001358615,0.00005396299,0.00002111704,0.00005243472,0.0000228378,0.00003854178,0.9963012,0.00008577224,0.00001860215,0.001708794],"study_design_scores_gemma":[0.00003031146,0.0004684484,0.03872703,0.00001250322,0.00005518851,0.001345993,0.00005562337,0.000477647,0.9564127,0.0003202412,0.002083004,0.00001121687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915106,0.001422056,0.005827502,0.00003824163,0.00003245389,0.00002830189,0.0004368148,0.00003863831,0.0006653468],"genre_scores_gemma":[0.9918069,0.000781595,0.005129297,0.00006164644,0.00001827359,0.00005012828,0.0009834345,0.00003815305,0.001130418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001124999,"threshold_uncertainty_score":0.003763497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02267079692379199,"score_gpt":0.2342768733121733,"score_spread":0.2116060763883812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}