{"id":"W1543437968","doi":"10.4049/jimmunol.180.5.3366","title":"Blockade of Antimicrobial Proteins S100A8 and S100A9 Inhibits Phagocyte Migration to the Alveoli in Streptococcal Pneumonia","year":2008,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"Université Laval","keywords":"S100A9; S100A8; Phagocyte; Immunology; CXCL2; Chemokine; Biology; CXCL1; Innate immune system; Streptococcus pneumoniae; Antimicrobial peptides; CCL2; Chemotaxis; Microbiology; Immune system; Antimicrobial; Inflammation; Chemokine receptor; Antibiotics; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002353069,0.0004747602,0.0005485956,0.0001908621,0.0001717711,0.0002000774,0.0002234021,0.0003781604,0.0007640582],"category_scores_gemma":[0.000139902,0.0001340755,0.0002320474,0.0001321521,0.0002552034,0.0001916848,0.0002075664,0.0008551609,0.0002974172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002544849,"about_ca_system_score_gemma":0.0002748304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004660611,"about_ca_topic_score_gemma":0.001051159,"domain_scores_codex":[0.9997705,0.000062381,0.00002098496,0.0000202734,0.00004939927,0.00007654824],"domain_scores_gemma":[0.9998823,0.00002102724,0.00002309256,0.00000952599,0.000008971399,0.0000550043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007878811,0.00037652,0.0002472312,0.00005419143,0.000007945022,0.00006244556,0.00001415682,0.00009450314,0.9955997,0.00003849332,0.00005830838,0.002658526],"study_design_scores_gemma":[0.000193379,0.008497359,0.009891952,0.00001305226,0.00003670759,0.0003106638,0.00004339577,0.002887935,0.9760122,0.00006720217,0.002039551,0.000006696511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974474,0.001084968,0.0006446154,0.00007173785,0.00003560583,0.00003236242,0.00005881308,0.00003401961,0.0005905547],"genre_scores_gemma":[0.9972811,0.0006288242,0.0009144524,0.00003667916,0.0000146541,0.00004899666,0.0001234243,0.000006115912,0.0009458676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007640582,"threshold_uncertainty_score":0.002556086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008755035995398633,"score_gpt":0.2247291477417991,"score_spread":0.2159741117464005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}