{"id":"W1543578687","doi":"10.1111/j.1600-0625.2011.01288.x","title":"CD109 release from the cell surface in human keratinocytes regulates TGF-β receptor expression, TGF-β signalling and STAT3 activation: relevance to psoriasis","year":2011,"lang":"en","type":"article","venue":"Experimental Dermatology","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Psoriasis; Keratinocyte; Downregulation and upregulation; Epidermis (zoology); Transforming growth factor; Cancer research; Signal transduction; Biology; Receptor; Cell biology; Chemistry; Immunology; Cell culture; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006831907,0.0002485886,0.0002246754,0.00003247279,0.0002150195,0.00003287365,0.0002895514,0.0001673521,0.0001930059],"category_scores_gemma":[0.00007515823,0.0002166555,0.00004881032,0.00008120781,0.0001457799,0.00001816952,0.0002227081,0.0001207588,0.0000210554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002640131,"about_ca_system_score_gemma":0.00004250263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001683174,"about_ca_topic_score_gemma":0.00002242752,"domain_scores_codex":[0.9984304,0.0002188097,0.0003624354,0.0005577796,0.0001264451,0.00030417],"domain_scores_gemma":[0.9991992,0.000101604,0.0001281406,0.0003938167,0.00004366761,0.0001336476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002676512,0.0001719301,0.007587119,0.000009026322,0.00001869519,0.000009242871,0.00210604,0.00008001315,0.9856647,0.00003067343,0.004010054,0.00004485108],"study_design_scores_gemma":[0.000696995,0.0001060316,0.002190236,0.0000532278,0.000006391432,0.000007005322,0.001427297,0.00002405896,0.9927052,0.00007450995,0.002446005,0.0002630146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945431,0.004367887,0.0002745981,0.0001340643,0.000124678,0.0003051141,0.0000230547,0.00003093848,0.0001965801],"genre_scores_gemma":[0.9930931,0.00004467265,0.005919658,0.0004925187,0.00009072482,0.00006959547,0.0001465798,0.00003752294,0.0001056401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007040523,"threshold_uncertainty_score":0.8834954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0157619248546246,"score_gpt":0.2537323658350021,"score_spread":0.2379704409803775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}