{"id":"W1543589984","doi":"10.18433/j3r30t","title":"Cationic Solid Lipid Nanoparticles Loaded by Cystein Proteinase Genes as a Novel anti-Leishmaniasis DNA Vaccine Delivery System: Characterization and in vitro Evaluations","year":2010,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Pasteur Institute of Iran; Tehran University of Medical Sciences and Health Services","keywords":"Cytotoxicity; Gene delivery; DNA vaccination; Visceral leishmaniasis; Chemistry; Zeta potential; Transfection; In vitro; Leishmania donovani; Molecular biology; Leishmaniasis; Biochemistry; Biology; Immunology; DNA; Nanoparticle; Materials science; Nanotechnology; Gene; Plasmid","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002101847,0.0003005312,0.0001845708,0.0002200927,0.0000907966,0.0002123667,0.000182397,0.0003401706,0.0003680735],"category_scores_gemma":[0.0001908647,0.0001303678,0.0001849303,0.0001633485,0.0001938942,0.0002421827,0.0001497977,0.0002138011,0.0002093026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002645724,"about_ca_system_score_gemma":0.0001421393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004167703,"about_ca_topic_score_gemma":0.0005367397,"domain_scores_codex":[0.9998784,0.00001879733,0.00001072855,0.00003200225,0.00004512735,0.0000149093],"domain_scores_gemma":[0.9999036,0.00001679953,0.00003210638,0.00000537049,0.00002831206,0.00001386405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003378659,0.00001571826,0.00005234467,0.0000545206,0.0000028584,0.00002859056,0.00001381247,0.0001628136,0.9987428,0.00003157306,0.00001438054,0.0008468619],"study_design_scores_gemma":[0.000006561542,0.0003172307,0.0003680018,0.00000425183,0.000009616636,0.0000658349,0.000009356165,0.001079525,0.9971653,0.00001212954,0.0009579918,0.00000417951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895029,0.001617345,0.007738516,0.00007864439,0.00002259871,0.0000630482,0.0001436373,0.00006187911,0.0007713236],"genre_scores_gemma":[0.9887122,0.001004519,0.007724622,0.00004018532,0.000007411034,0.00006729813,0.0002654536,0.00001932546,0.002158944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004167703,"threshold_uncertainty_score":0.001919627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05643173754734544,"score_gpt":0.3994257322489618,"score_spread":0.3429939947016164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}