{"id":"W1543589984","doi":"10.18433/j3r30t","title":"Cationic Solid Lipid Nanoparticles Loaded by Cystein Proteinase Genes as a Novel anti-Leishmaniasis DNA Vaccine Delivery System: Characterization and in vitro Evaluations","year":2010,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Pasteur Institute of Iran; Tehran University of Medical Sciences and Health Services","keywords":"Cytotoxicity; Gene delivery; DNA vaccination; Visceral leishmaniasis; Chemistry; Zeta potential; Transfection; In vitro; Leishmania donovani; Molecular biology; Leishmaniasis; Biochemistry; Biology; Immunology; DNA; Nanoparticle; Materials science; Nanotechnology; Gene; Plasmid","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002732244,0.000238393,0.0005306383,0.0004390329,0.0003474266,0.000192092,0.0003307929,0.0000582822,0.0001438546],"category_scores_gemma":[0.0007499146,0.0001818617,0.0001037406,0.0009023523,0.0003952295,0.0009688214,0.0001319689,0.0006024261,0.00001941223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001529382,"about_ca_system_score_gemma":0.0005627231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006553096,"about_ca_topic_score_gemma":0.0000150137,"domain_scores_codex":[0.9966423,0.0002272841,0.0009480881,0.0003851801,0.001247635,0.0005495142],"domain_scores_gemma":[0.9979891,0.0002469953,0.0004159837,0.0001497326,0.0006816185,0.0005165993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005891673,0.0005271804,0.008853492,0.0001712925,0.00007241817,0.0001046504,0.0001788775,0.000008728207,0.9616485,0.00003168863,0.00008983639,0.02772416],"study_design_scores_gemma":[0.004749616,0.0002270563,0.01303369,0.0001532488,0.0002185078,0.001615687,0.0002618689,0.01428905,0.9588773,0.000005999249,0.006384713,0.0001832914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865895,0.001261775,0.0001524262,0.01066375,0.0003441394,0.0008640037,0.00002135631,0.00002958455,0.00007345083],"genre_scores_gemma":[0.9974964,0.000929679,0.0006558907,0.0003593122,0.0004280029,0.00005268458,0.000008870366,0.00001793236,0.0000511867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02754087,"threshold_uncertainty_score":0.7416105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05643173754734544,"score_gpt":0.3994257322489618,"score_spread":0.3429939947016164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}