{"id":"W1544045643","doi":"10.1016/j.stemcr.2015.06.011","title":"Activating Endogenous Neural Precursor Cells Using Metformin Leads to Neural Repair and Functional Recovery in a Model of Childhood Brain Injury","year":2015,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Canada Research Chairs; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research","keywords":"Neurogenesis; Neural stem cell; Metformin; Endogeny; Biology; Progenitor cell; Precursor cell; Neuroscience; Subventricular zone; Stem cell; Endocrinology; Cell biology; Cell; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001741009,0.0004179199,0.0004661986,0.0005485179,0.0002592363,0.0002650617,0.0003165115,0.0003774761,0.00163572],"category_scores_gemma":[0.0001335319,0.0001443185,0.0002723857,0.0003107716,0.0004505039,0.0003112152,0.0002586081,0.001103127,0.0002690007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003395807,"about_ca_system_score_gemma":0.0005808693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001444452,"about_ca_topic_score_gemma":0.003020167,"domain_scores_codex":[0.9998668,0.00001697932,0.00001635363,0.00002216917,0.00003617715,0.00004141872],"domain_scores_gemma":[0.9998379,0.00002096845,0.00005664506,0.00001602331,0.00001008603,0.0000583278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001240992,0.0003530599,0.0005068641,0.0001461794,0.00002048247,0.0004148308,0.00009093147,0.0002861825,0.9900925,0.0004164516,0.000238812,0.006192726],"study_design_scores_gemma":[0.00004610202,0.001464663,0.003569196,0.00002173597,0.00003115815,0.0003395462,0.0001171385,0.0006110161,0.9920284,0.00009134365,0.001671102,0.000008554741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960504,0.001039205,0.001372388,0.0001550407,0.00006329373,0.00003889296,0.0002891684,0.00006719255,0.0009244684],"genre_scores_gemma":[0.9886373,0.003141204,0.003401651,0.0001005308,0.00001841973,0.0001148906,0.0006062166,0.00003352383,0.003946405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00163572,"threshold_uncertainty_score":0.005472064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0984896902157424,"score_gpt":0.3019384325414668,"score_spread":0.2034487423257244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}