{"id":"W1544449882","doi":"10.1016/s0079-6603(01)69044-5","title":"Regulation of the DNA methylation machinery and its role in cellular transformation","year":2001,"lang":"en","type":"review","venue":"Progress in nucleic acid research and molecular biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"DNA methylation; Biology; RNA-Directed DNA Methylation; Epigenetics of physical exercise; DNMT1; Epigenomics; Demethylase; Methylation; Methyltransferase; DNA methyltransferase; Methylated DNA immunoprecipitation; Cancer epigenetics; DNA replication; DNA; Epigenetics; Genetics; Molecular biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007696361,0.0009842931,0.001660133,0.00125898,0.0003793182,0.001396071,0.00166657,0.001551825,0.001663413],"category_scores_gemma":[0.0005261558,0.0003805669,0.0003048483,0.001878895,0.001458839,0.001721904,0.0008140706,0.001951197,0.001606873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001032367,"about_ca_system_score_gemma":0.0008321636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001107723,"about_ca_topic_score_gemma":0.001512029,"domain_scores_codex":[0.9997973,0.00002891741,0.00002181854,0.00004886452,0.00007225222,0.00003096148],"domain_scores_gemma":[0.9997743,0.00009904756,0.00003173171,0.00001542082,0.00005352834,0.00002601419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002264107,0.00006359471,0.0003682314,0.006538509,0.00007033435,0.0006525608,0.0001223697,0.00125934,0.033019,0.01956796,0.02067537,0.9174364],"study_design_scores_gemma":[0.00003756462,0.00007646238,0.001421867,0.000676258,0.00007054547,0.001815002,0.0001139397,0.0002760286,0.009914409,0.01145242,0.9741117,0.00003385325],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003914824,0.9966697,0.0008951025,0.0003999843,0.0003606118,0.000005206649,0.00001497999,0.00001590496,0.001247022],"genre_scores_gemma":[0.003076642,0.994556,0.0005605805,0.0002171025,0.0003859836,0.0000109376,0.00003117501,0.000002641061,0.001159079],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00166657,"threshold_uncertainty_score":0.007490396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03483497728364793,"score_gpt":0.3701402515010334,"score_spread":0.3353052742173855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}